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Studies on the antioxidative activity of phloroglucinol derivatives isolated from hypericum species

Heilmann, Jörg, Winkelmann, K. and Sticher, Otto (2003) Studies on the antioxidative activity of phloroglucinol derivatives isolated from hypericum species. Planta medica 69 (3), pp. 202-206.

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Abstract

Twenty-one phloroglucinol derivs., belonging to 8 different carbon skeletons, were tested for their ability to influence the oxidative burst of polymorphonuclear cells (PMNs) after stimulation with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or opsonized zymosan (OZ). Results revealed a strong redn. of oxygen prodn. by PMNs after stimulation with fMLP for the compds. ialibinone E (5), ...

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Item type:Article
Date:2003
Additional Information (public):CAN 139:159442 1-3 Pharmacology 7782-44-7D (Oxygen); 9002-17-9 (Xanthine oxidase); 9007-43-6 (Cytochrome c) Role: BSU (Biological study, unclassified), BIOL (Biological study) (antioxidant activity of phloroglucinol derivs. from hypericum species); 11079-53-1 (Hyperforin); 256471-46-2 (Ialibinone A); 256471-47-3 (Ialibinone B); 256471-48-4 (Ialibinone C); 256471-49-5 (Ialibinone D); 256471-50-8 (Ialibinone E); 350027-98-4 (Papuaforin A); 350027-99-5 (Papuaforin B); 350028-00-1 (Papuaforin C); 350028-01-2 (Papuaforin D); 350028-02-3 (Papuaforin E); 350028-03-4 (Hyperguinone A); 350028-04-5 (Hyperguinone B); 350028-05-6 (Hyperpapuanone); 398119-01-2 (Enaimeone A); 398119-02-3 (Enaimeone B); 398119-03-4 (Enaimeone C); 398119-04-5 (1'-Hydroxyialibinone A); 398119-05-6 (1'-Hydroxyialibinone B); 398119-06-7 (1'-Hydroxyialibinone D); 398119-08-9 (Furonewguinone B) Role: NPO (Natural product occurrence), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (antioxidant activity of phloroglucinol derivs. from hypericum species)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2003:320817Other
Keywords:Antioxidants Cytotoxicity Hypericum Radical scavengers Structure-activity relationship (antioxidant activity of phloroglucinol derivs. from hypericum species) Reactive oxygen species Role: BSU (Biological study, unclassified), BIOL (Biological study) (antioxidant activity of phloroglucinol derivs. from hypericum species) Respiration (burst antioxidant activity of phloroglucinol derivs. from hypericum species) antioxidant phloroglucinol deriv hypericum structure activity
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17214
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