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Studies on the antioxidative activity of phloroglucinol derivatives isolated from hypericum species

Heilmann, Jörg ; Winkelmann, K. ; Sticher, Otto


Twenty-one phloroglucinol derivs., belonging to 8 different carbon skeletons, were tested for their ability to influence the oxidative burst of polymorphonuclear cells (PMNs) after stimulation with N-formyl-methionyl-leucyl-phenylalanine (fMLP) or opsonized zymosan (OZ). Results revealed a strong redn. of oxygen prodn. by PMNs after stimulation with fMLP for the compds. ialibinone E (5), ...


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