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Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-Type sesquiterpene lactones

Hilmi, Fatima ; Gertsch, Jurg ; Bremner, Paul ; Valovic, Silvia ; Heinrich, Michael ; Sticher, Otto ; Heilmann, Jörg



Abstract

Four guaianolide type sesquiterpene lactones (SL), namely the new 1,2-dihydro-3-oxo-costic acid guaianyl ester 3beta -O-(1,2-didehydro-3-oxo-costoyloxy)-4beta ,10beta -dihydroxy-guaia-1(2)-en-6beta ,12-olide (1) and 3beta -O-(1,2-didehydro-3-oxo-costoyloxy)-4beta ,10beta -dihydroxy-guaia-1(2)-en-6alpha ,12-olide (2), as well as the known moroccolide A [5alpha H-2beta ,4-epoxy-3beta ...

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