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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Planta medica | ||||
| Publisher: | Thieme | ||||
| Volume: | 69 | ||||
| Number of Issue or Book Chapter: | 5 | ||||
| Page Range: | pp. 462-464 | ||||
| Date: | 2003 | ||||
| Additional Information (public): | CAN 139:393383 11-1 Plant Biochemistry 28254-53-7P (Reynosin); 36150-07-9P (Dehydroleucodin); 76937-87-6P; 137624-15-8P Role: BSU (Biological study, unclassified), PUR (Purification or recovery), BIOL (Biological study), PREP (Preparation) (cytotoxic sesquiterpene lactones from Warionia saharae); 625455-63-2P; 625455-64-3P; 625455-65-4P Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (new cytotoxic sesquiterpene lactones from Warionia saharae) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) | ||||
| Identification Number: |
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| Keywords: | Toxins Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxins new cytotoxic sesquiterpene lactones from Warionia saharae) Sesquiterpenes Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (lactones new cytotoxic sesquiterpene lactones from Warionia saharae) Antitumor agents Warionia saharae (new cytotoxic sesquiterpene lactones from Warionia saharae) sesquiterpene lactone antitumor agent Warionia | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | No | ||||
| Item ID: | 17216 |
Abstract
Cytotoxicity-guided fractionation of the MeOH-sol. part of the CH2Cl2 ext. of the leaves of W. saharae led to the isolation of the 2 new guaianolide-type sesquiterpene lactones, 5alpha H-3beta ,4beta -epoxy-14-oxo-guaia-1(10),11(13)-dien-6alpha ,12-olide (I), 5alpha H-2beta ,4beta -epoxy-3alpha -hydroxy-guaia-1(10),11(13)-dien-6alpha ,12-olide (II), and the new eudesmane type sesquiterpene 1beta ...
Abstract
Cytotoxicity-guided fractionation of the MeOH-sol. part of the CH2Cl2 ext. of the leaves of W. saharae led to the isolation of the 2 new guaianolide-type sesquiterpene lactones, 5alpha H-3beta ,4beta -epoxy-14-oxo-guaia-1(10),11(13)-dien-6alpha ,12-olide (I), 5alpha H-2beta ,4beta -epoxy-3alpha -hydroxy-guaia-1(10),11(13)-dien-6alpha ,12-olide (II), and the new eudesmane type sesquiterpene 1beta ,6alpha -dihydroxycostic acid (III). In addn., the known sesquiterpene lactones 5alpha H-2beta -hydroxyguaia-3(4),10(14),11(13)-trien-6alpha ,12-olide (IV), reynosin, 5alpha H-1alpha ,10alpha :3alpha ,4alpha -diepoxyguaia-11(13)-en-6alpha ,12-olide (V), and dehydroleucodin were isolated together with the known flavone hispidulin. Cytotoxicity testing of the sesquiterpene lactones against the KB cancer cell line (ATCC CCL17) revealed IC50 values of 3.5 (I), 2.6 (IV), 2.7 (reynosin), 4.3 (V), 3.6 (II), and 1.3 (dehydroleucodin) micro g/mL. III was not active up to 20 micro g/mL.
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