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New cytotoxic sesquiterpene lactones from Warionia saharae

Hilmi, Fatima ; Sticher, Otto ; Heilmann, Jörg



Abstract

Cytotoxicity-guided fractionation of the MeOH-sol. part of the CH2Cl2 ext. of the leaves of W. saharae led to the isolation of the 2 new guaianolide-type sesquiterpene lactones, 5alpha H-3beta ,4beta -epoxy-14-oxo-guaia-1(10),11(13)-dien-6alpha ,12-olide (I), 5alpha H-2beta ,4beta -epoxy-3alpha -hydroxy-guaia-1(10),11(13)-dien-6alpha ,12-olide (II), and the new eudesmane type sesquiterpene 1beta ...

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