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New cytotoxic sesquiterpene lactones from Warionia saharae

Hilmi, Fatima, Sticher, Otto and Heilmann, Jörg (2003) New cytotoxic sesquiterpene lactones from Warionia saharae. Planta medica 69 (5), pp. 462-464.

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Abstract

Cytotoxicity-guided fractionation of the MeOH-sol. part of the CH2Cl2 ext. of the leaves of W. saharae led to the isolation of the 2 new guaianolide-type sesquiterpene lactones, 5alpha H-3beta ,4beta -epoxy-14-oxo-guaia-1(10),11(13)-dien-6alpha ,12-olide (I), 5alpha H-2beta ,4beta -epoxy-3alpha -hydroxy-guaia-1(10),11(13)-dien-6alpha ,12-olide (II), and the new eudesmane type sesquiterpene 1beta ...

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Item type:Article
Date:2003
Additional Information (public):CAN 139:393383 11-1 Plant Biochemistry 28254-53-7P (Reynosin); 36150-07-9P (Dehydroleucodin); 76937-87-6P; 137624-15-8P Role: BSU (Biological study, unclassified), PUR (Purification or recovery), BIOL (Biological study), PREP (Preparation) (cytotoxic sesquiterpene lactones from Warionia saharae); 625455-63-2P; 625455-64-3P; 625455-65-4P Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (new cytotoxic sesquiterpene lactones from Warionia saharae)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2003:512793Other
Keywords:Toxins Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (cytotoxins new cytotoxic sesquiterpene lactones from Warionia saharae) Sesquiterpenes Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), PUR (Purification or recovery), BIOL (Biological study), OCCU (Occurrence), PREP (Preparation) (lactones new cytotoxic sesquiterpene lactones from Warionia saharae) Antitumor agents Warionia saharae (new cytotoxic sesquiterpene lactones from Warionia saharae) sesquiterpene lactone antitumor agent Warionia
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17216
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