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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Veterinary parasitology | ||||
| Publisher: | Elsevier | ||||
| Volume: | 117 | ||||
| Number of Issue or Book Chapter: | 1-2 | ||||
| Page Range: | pp. 51-60 | ||||
| Date: | 2003 | ||||
| Additional Information (public): | Netherlands | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) | ||||
| Identification Number: |
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| Keywords: | Administration, Oral Animals Anthelmintics: AD, administration & dosage *Anthelmintics: TU, therapeutic use Feces: PS, parasitology Haemonchiasis: DT, drug therapy *Haemonchiasis: VE, veterinary Haemonchus: DE, drug effects Haemonchus: GD, growth & development Intestinal Diseases, Parasitic: DT, drug therapy Intestinal Diseases, Parasitic: VE, veterinary Parasite Egg Count: VE, veterinary *Phytotherapy Phytotherapy: VE, veterinary Plant Extracts: AD, administration & dosage *Plant Extracts: TU, therapeutic use Random Allocation Sheep *Sheep Diseases: DT, drug therapy Trichostrongylosis: DT, drug therapy *Trichostrongylosis: VE, veterinary Trichostrongylus: DE, drug effects Trichostrongylus: GD, growth & development 0 (Anthelmintics) 0 (Plant Extracts) | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | No | ||||
| Item ID: | 17217 |
Abstract
Forty-eight helminth-free lambs were divided into eight groups (A-H) of six animals. Groups A-G were infected artificially with 10,000 third stage larvae of Haemonchus contortus and 20,000 third stage larvae of Trichostrongylus colubriformis, whereas group H remained uninfected. Thirty days post-infection the lambs were treated orally with a single dosage of one of the following products: group A ...
Abstract
Forty-eight helminth-free lambs were divided into eight groups (A-H) of six animals. Groups A-G were infected artificially with 10,000 third stage larvae of Haemonchus contortus and 20,000 third stage larvae of Trichostrongylus colubriformis, whereas group H remained uninfected. Thirty days post-infection the lambs were treated orally with a single dosage of one of the following products: group A with 3 mg/kg body weight (BW) of an aqueous ethanol extract (70%, v/v) of the seeds of Azadirachta indica A. Juss syn. Melia azedarach L. (Meliaceae); group B with 1 g/kg BW of a raw powder of the leaves of Ananas comosus (L.) Merr. (Bromeliaceae); group C with 0.3 mg/kg BW of an aqueous ethanol extract of a 1:1 mixture (g/g) of Vernonia anthelmintica (L.) Willd. (Asteraceae) seeds and Embelia ribes Burm (Myrsinaceae) fruits; group D with 183 mg/kg BW of an aqueous ethanol extract of the whole plants of Fumaria parviflora Lam. (Fumariaceae); group E with 28 mg/kg BW of an aqueous ethanol extract of the seeds of Caesalpinia crista L. (Caesalpiniaceae); group F with 25 mg/kg BW of pyrantel tartrate and group G with 50% ethanol. Group H remained untreated. Only the ethanol extract of F. parviflora caused a strong reduction of the faecal egg counts (100%) and a 78.2 and 88.8% reduction of adult H. contortus and T. colubriformis on day 13 post-treatment. The extract was as effective as the reference compound pyrantel tartrate. Therefore, the ethanol extract itself or single constituents of F. parviflora could be a promising alternative source of anthelmintic for the treatment of gastrointestinal trichostrongylids in small ruminants.
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