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New Chromanone Acids with Antibacterial Activity from Calophyllum brasiliense

Cottiglia, Filippo, Dhanapal, Boopathy, Sticher, Otto and Heilmann, Jörg (2004) New Chromanone Acids with Antibacterial Activity from Calophyllum brasiliense. Journal of natural products 67 (4), pp. 537-541.

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Abstract

Six novel chromanone acids were isolated from the bark of Calophyllum brasiliense Cambess. Their structures were elucidated on the basis of 1D and 2D NMR expts., as well as mass spectrometry. All compds. showed moderate to strong antibacterial activity against Bacillus cereus and Staphylococcus epidermidis, with two of them being most active. None of the compds. were cytotoxic against KB, Jurkat T, and myosarcoma cancer cells used in concns. up to 20 micro g/mL.


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Item type:Article
Date:2004
Additional Information (public):CAN 140:353662 11-1 Plant Biochemistry 682334-57-2 (Brasilienosophyllic acid A); 682334-58-3 (Isobrasilienosophyllic acid A); 682334-59-4 (Brasilienosophyllic acid B); 682334-60-7 (Isobrasilienosophyllic acid B); 682334-61-8 (Brasilienosophyllic acid C); 682334-62-9 (Isobrasilienosophyllic acid C) Role: BSU (Biological study, unclassified), NPO (Natural product occurrence), PRP (Properties), BIOL (Biological study), OCCU (Occurrence) (new chromanone acids with antibacterial activity from Calophyllum brasiliense)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2004:153497Other
Keywords:Antibacterial agents Bacillus cereus Bark Calophyllum brasiliense Staphylococcus epidermidis (new chromanone acids with antibacterial activity from Calophyllum brasiliense) Molecular structure (of chromanone acids from Calophyllum brasiliense) chromanone acid antibacterial Calophyllum brasiliense mol structure
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:17220
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