Alternative links to fulltext:
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Phytochemistry | ||||
| Publisher: | Elsevier | ||||
| Volume: | 68 | ||||
| Number of Issue or Book Chapter: | 11 | ||||
| Page Range: | pp. 1587-1594 | ||||
| Date: | 2007 | ||||
| Additional Information (public): | CAN 147:203316 1-6 Pharmacology 465-92-9P; 19898-90-9P; 19906-99-1P; 72010-01-6P; 72029-64-2P; 170554-74-2P; 175861-92-4P; 176019-14-0P; 857901-78-1P; 857901-80-5P; 858341-33-0P; 944795-71-5P; 944795-73-7P Role: PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) | ||||
| Identification Number: |
| ||||
| Keywords: | Antitumor agents Cytotoxicity Human Immunosuppressants Lymphocyte Marrubium cylleneum Marrubium velutinum Molecular structure Natural products (labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) Diterpenes Role: PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (labdane labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) Diterpenes Role: PAC (Pharmacological activity), PRP (Properties), PUR (Purification or recovery), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (norditerpenes labdane diterpenes from Marrubium cylleneum and Marrubium velutinum, purifn., mol. structure, cytotoxicity, and immunomodulation) labdane diterpene Marrubium mol structure cytotoxicity immunomodulator antitumor | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 17231 |
Abstract
From the aerial parts of Marrubium cylleneum, 1 labdane nor-diterpene was isolated together with 2 labdane diterpenes, hitherto not known as natural products. The structures of the isolated compds. were established by means of NMR [1H-1H-COSY, 1H-13C-HSQC, HMQC-TOCSY, HMBC, NOESY] and MS spectral analyses. Several diterpenoids from M. cylleneum and M. velutinum were tested for their cytotoxic ...
Abstract
From the aerial parts of Marrubium cylleneum, 1 labdane nor-diterpene was isolated together with 2 labdane diterpenes, hitherto not known as natural products. The structures of the isolated compds. were established by means of NMR [1H-1H-COSY, 1H-13C-HSQC, HMQC-TOCSY, HMBC, NOESY] and MS spectral analyses. Several diterpenoids from M. cylleneum and M. velutinum were tested for their cytotoxic effect against various cancer cell lines and their immunomodulating potential in human peripheral blood mononuclear cells in std. in vitro assays. The results show a differential cytotoxicity of some compds. as well as their ability to improve selected lymphocyte functions.
Metadata last modified: 24 May 2018 12:16
Owner only: item control page
Altmetric