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Cytotoxicity and immunomodulating characteristics of labdane diterpenes from Marrubium cylleneum and Marrubium velutinum

Karioti, Anastasia ; Skopeliti, Margarita ; Tsitsilonis, Ourania ; Heilmann, Jörg ; Skaltsa, Helen


From the aerial parts of Marrubium cylleneum, 1 labdane nor-diterpene was isolated together with 2 labdane diterpenes, hitherto not known as natural products. The structures of the isolated compds. were established by means of NMR [1H-1H-COSY, 1H-13C-HSQC, HMQC-TOCSY, HMBC, NOESY] and MS spectral analyses. Several diterpenoids from M. cylleneum and M. velutinum were tested for their cytotoxic ...


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