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Synthesis and cannabinoid receptor activity of ketoalkenes from echinacea pallida and nonnatural analogues

Egger, Michael ; Pellett, Patrina ; Nickl, Kathrin ; Geiger, Sarah ; Graetz, Stephanie ; Seifert, Roland ; Heilmann, Jörg ; Koenig, Burkhard


Despite its popularity and widespread use, the efficacy of Echinacea products remains unclear and controversial. Among the various compds. isolated from Echinacea, ketoalkenes and ketoalkenynes exclusively found in the pale purple coneflower (E. pallida) are major components of the exts. In contrast to E. purpurea alkamides, these compds. have not been synthesized and studied for ...


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