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Synthesis and cannabinoid receptor activity of ketoalkenes from echinacea pallida and nonnatural analogues

Egger, Michael, Pellett, Patrina, Nickl, Kathrin, Geiger, Sarah, Graetz, Stephanie, Seifert, Roland, Heilmann, Jörg und Koenig, Burkhard (2008) Synthesis and cannabinoid receptor activity of ketoalkenes from echinacea pallida and nonnatural analogues. Chemistry: a European journal 14 (35), S. 10978-10987.

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Zusammenfassung

Despite its popularity and widespread use, the efficacy of Echinacea products remains unclear and controversial. Among the various compds. isolated from Echinacea, ketoalkenes and ketoalkenynes exclusively found in the pale purple coneflower (E. pallida) are major components of the exts. In contrast to E. purpurea alkamides, these compds. have not been synthesized and studied for ...

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Dokumentenart:Artikel
Datum:2008
Zusätzliche Informationen (Öffentlich):CAN 150:237281 26-9 Biomolecules and Their Synthetic Analogs 13965-03-2 (Bis(triphenylphosphine)dichloropalladium) Role: CAT (Catalyst use), USES (Uses) (prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity); 1115909-04-0P Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity); 149301-78-0P; 1115909-10-8P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity); 107-19-7 (Propargyl alcohol); 502-42-1 (Cycloheptanone); 506-32-1; 536-74-3; 590-13-6 ((Z)-1-Bromo-1-propene); 590-15-8 ((E)-1-Bromo-1-propene); 928-94-9 ((Z)-2-Hexen-1-ol); 1066-54-2; 6089-04-9 (1-(Tetrahydropyranyloxy)-2-propyne) Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity); 3761-94-2P; 20739-58-6P (2-Octyn-1-ol); 26001-58-1P; 26806-12-2P; 36602-98-9P; 53384-66-0P; 56922-75-9P; 60099-86-7P; 66432-72-2P; 75359-52-3P; 80639-28-7P; 82168-14-7P; 108965-88-4P; 122712-60-1P; 343950-99-2P; 1115908-75-2P; 1115908-92-3P; 1115908-96-7P; 1115908-98-9P; 1115909-00-6P; 1115909-02-8P; 1115909-06-2P; 1115909-08-4P; 1115909-15-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity); 57221-86-0P; 116752-10-4P; 118853-86-4P; 118853-87-5P; 214041-70-0P; 1115909-12-0P; 1115909-17-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2009:9545Andere
Stichwörter / Keywords:Structure-activity relationship (cannabinoid prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity) Cross-coupling reaction Cross-coupling reaction catalysts Echinacea pallida Human (prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity) Cannabinoid receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (type CB1 prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity) Cannabinoid receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (type CB2 prepn. of ketoalkenes from echinacea pallida and non-natural analogs by Pd-catalyzed cross-coupling and cannabinoid receptor activity) ketoalkene echinacea pallida synthesis analog cannabinoid receptor agonist cross coupling palladium ketoalkene synthesis
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:18 Okt 2010 13:30
Zuletzt geändert:08 Mrz 2017 08:27
Dokumenten-ID:17238
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