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Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

Fang, Lei ; Kraus, Birgit ; Lehmann, Jochen ; Heilmann, Jörg ; Zhang, Yihua ; Decker, Michael



Abstract

Five tacrine-ferulic acid hybrids were designed and synthesized as multi-potent anti-Alzheimer drug candidates. All target compds. have better acetylcholinesterase inhibitory activity and comparable butyrylcholinesterase inhibitory activity in relation to tacrine. Interestingly, I showed a reversible and non-competitive inhibitory action for acetylcholinesterase indicating interaction with the ...

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