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Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates
Fang, Lei, Kraus, Birgit, Lehmann, Jochen, Heilmann, Jörg, Zhang, Yihua and Decker, Michael (2008) Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates. Bioorganic & medicinal chemistry letters 18 (9), pp. 2905-2909.Date of publication of this fulltext: 18 Oct 2010 13:31
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| Item type | Article | ||||
| Journal or Publication Title | Bioorganic & medicinal chemistry letters | ||||
| Publisher: | Elsevier | ||||
|---|---|---|---|---|---|
| Volume: | 18 | ||||
| Number of Issue or Book Chapter: | 9 | ||||
| Page Range: | pp. 2905-2909 | ||||
| Date | 2008 | ||||
| Additional Information (public) | CAN 149:129007 31-5 Alkaloids 9000-81-1 (Acetylcholinesterase); 9001-08-5 (Cholinesterase) Role: BSU (Biological study, unclassified), BIOL (Biological study) (inhibitors; synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 321-64-2 (Tacrine); 1135-24-6 (Ferulic acid) Role: PAC (Pharmacological activity), BIOL (Biological study) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 57165-75-0P; 249290-07-1P; 249290-16-2P; 249290-19-5P; 844874-03-9P Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 1036298-17-5P; 1036298-18-6P; 1036298-19-7P; 1036298-20-0P; 1036298-21-1P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 107-15-3 (1,2-Ethanediamine); 109-76-2 (1,3-Propanediamine); 110-60-1 (1,4-Butanediamine); 373-44-4 (1,8-Octanediamine); 462-94-2 (1,5-Pentanediamine); 537-98-4; 541-41-3; 5396-30-5 Role: RCT (Reactant), RACT (Reactant or reagent) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates); 62621-20-9P; 1036298-12-0P; 1036298-13-1P; 1036298-14-2P; 1036298-15-3P; 1036298-16-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates) | ||||
| Institutions | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) | ||||
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| Keywords | Structure-activity relationship (antioxidant synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates) Amines Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (diamines synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates) Alkaloids Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), RACT (Reactant or reagent) (quinoline synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates) Anti-Alzheimer's agents Cholinesterase inhibitors (synthesis, antioxidant activity, and acetylcholinesterase and butyrylcholinesterase inhibition of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates) tacrine ferulic acid hybrid synthesis cholinesterase inhibitor antioxidant agent anti Alzheimer agent tacrine ferulic acid hydrid | ||||
| Dewey Decimal Classification | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| Item ID | 17239 |
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