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Synthesis, Cytotoxicity, and Antioxidative Activity of Minor Prenylated Chalcones from Humulus lupulus

Vogel, Susanne and Heilmann, Jörg (2008) Synthesis, Cytotoxicity, and Antioxidative Activity of Minor Prenylated Chalcones from Humulus lupulus. Journal of natural products 71 (7), pp. 1237-1241.

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Abstract

The minor hop (Humulus lupulus) chalcones 3'-geranylchalconaringenin (3), 5'-prenylxanthohumol (4), flavokawin (5), xanthohumol H (8), xanthohumol C (9), and 1'',2''-dihydroxanthohumol C (10) were synthesized. The non-natural chalcones 3'-geranyl-6'-O-methylchalconaringenin (2), 3'-methylflavokawin (6), and 2'-O-methyl-3'-prenylchalconaringenin (7) were also synthesized. Cytotoxicity was ...

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Item type:Article
Date:2008
Additional Information (public):CAN 149:246662 30-10 Terpenes and Terpenoids 6754-58-1 Role: PAC (Pharmacological activity), BIOL (Biological study) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells); 37308-75-1P; 189299-03-4P; 189299-04-5P; 189299-05-6P (Xanthohumol C); 250603-94-2P; 688359-98-0P (Xanthohumol H); 1044743-34-1P; 1044743-35-2P; 1044743-36-3P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells); 123-08-0 (4-Hydroxybenzaldehyde); 480-66-0; 870-63-3 (Prenyl bromide); 6138-90-5 (Geranyl bromide) Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells); 90-24-4P; 6515-21-5P; 23121-32-6P (2-Hydroxy-4,6-dimethoxy-3-methylacetophenone); 25983-76-0P; 27364-71-2P; 30403-01-1P; 32550-59-7P; 65490-09-7P; 84092-45-5P; 90632-20-5P; 160624-22-6P; 450336-12-6P; 955950-40-0P; 1044743-37-4P; 1044743-38-5P; 1044743-39-6P; 1044743-40-9P; 1044743-41-0P; 1044743-42-1P; 1044743-43-2P; 1044743-44-3P; 1075728-02-7P; 1173195-54-4P; 1173196-14-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2008:823843Other
Keywords:Antioxidants (phenolic prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells) Terpenes Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (phenolic prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells) Antitumor agents Neoplasm (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells) Chalcones Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa Phenols Role: PAC (Pharmacological activity), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (terpenoid prepn. of prenylated/geranylated chalcones from Humulus lupulus, and study of their antioxidative activity and cytotoxicity in HeLa cells) prenylated geranylated Humulus lupulus chalcone prepn antitumor antioxidative activity
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17242
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