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Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity

Vogel, Susanne ; Ohmayer, Susanne ; Brunner, Gabi ; Heilmann, Jörg


A general strategy for the synthesis of 3'-prenylated chalcones was established and a series of prenylated hydroxychalcones, including the hop (Humulus lupulus L.) secondary metabolites xanthohumol (1), desmethylxanthohumol (2), xanthogalenol (3), and 4-methylxanthohumol (4) were synthesized. The influence of the A-ring hydroxylation pattern on the cytotoxic activity of the prenylated chalcones ...


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