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Antioxidant Effects of Xanthohumol and Functional Impact on Hepatic Ischemia-Reperfusion Injury

Hartkorn, Andreas ; Hoffmann, Florian ; Ajamieh, Hussam ; Vogel, Susanne ; Heilmann, Jörg ; Gerbes, Alexander L. ; Vollmar, Angelika M. ; Zahler, Stefan



Abstract

Therapeutic effects of dietary flavonoids have been attributed mainly to their antioxidant capacity. Xanthohumol (1), a prominent flavonoid of the hop plant, Humulus lupulus, was investigated for its antioxidant potential and for its effect on NF-kB activation. To examine the biol. relevance of 1, a hepatic ischemia/reperfusion model was chosen as a widely accepted model of oxidative stress ...

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