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Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages

Kraus, Birgit ; Wolff, Horst ; Elstner, Erich F. ; Heilmann, Jörg



Abstract

Upon activation, microglia, the immunocompetent cells in the brain, get highly phagocytic and release pro-inflammatory mediators like nitric oxide (NO). Excessive NO prodn. is pivotal in neurodegenerative disorders, and there is evidence that abnormalities in NO prodn. and inflammatory responses may at least support a range of neuropsychiatric disorders, including depression. Although exts. of ...

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