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Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages

Kraus, Birgit, Wolff, Horst, Elstner, Erich F. and Heilmann, Jörg (2010) Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages. Naunyn-Schmiedebergs Archiv für Pharmakologie 381 (6), pp. 541-553.

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Abstract

Upon activation, microglia, the immunocompetent cells in the brain, get highly phagocytic and release pro-inflammatory mediators like nitric oxide (NO). Excessive NO prodn. is pivotal in neurodegenerative disorders, and there is evidence that abnormalities in NO prodn. and inflammatory responses may at least support a range of neuropsychiatric disorders, including depression. Although exts. of ...

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Item type:Article
Date:2010
Additional Information (public):15 Immunochemistry
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2010:593378Other
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17254
Owner only: item control page
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