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cis-Dichloropeptide ester-platinum(II) complexes

Beck, Wolfgang, Purucker, Bernhard, Girnth, Michael, Schönenberger, Helmut and Seidenberger, Horst (1977) cis-Dichloropeptide ester-platinum(II) complexes.

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Peptide complexes I (R, R1 = H, C1-4 alkyl, optionally substituted by OH, NH2, OMe, OEt, SH, SMe, SEt, CH2Ph, CH2C6H4OH, CH2C6H4OMe, CH2C6H4OEt; R2 = C1-4 alkyl; n = 1-3) were prepd. Thus cis-PtCl2(Gly-OH)2 was treated with 4-O2NC6H4OH and cis-PtCl2(Gly-OC6H4NO2-4)2 treated with H-Gly-OEt to give cis-PtCl2(Gly-Gly-OEt)2 (I). I had a min. inhibitory concn. against Escherichia coli B of 5 * 10-4 mol/L and inhibited DNA synthesis in Walker 256 carcinosarcoma at 4.5 * 10-7 mol/L.

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Item type:Patent
Additional Information (public):CAN 88:170495 34-3 Synthesis of Amino Acids, Peptides, and Proteins Patent 19771229 2087-41-4; 66156-95-4 Role: RCT (Reactant), RACT (Reactant or reagent) (complexation of, with chloroplatinate); 10025-99-7 Role: RCT (Reactant), RACT (Reactant or reagent) (complexation of, with dipeptides); 60426-60-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and bactericidal and carcinostatic activity of); 60426-61-1P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and peptide synthesis with); 60399-28-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 100-02-7; 459-73-4; 26348-61-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with glycine platinum complex); 17567-45-2 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with nitrophenol)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
76-2626559 2626559Other
Keywords:Bactericides, Disinfectants and Antiseptics (glycylglycine platinum complex) Neoplasm inhibitors (Walker 256 carcinosarcoma, glycylglycine platinum complex) Neoplasm inhibitors (sarcoma 180, glycylglycine platinum complex) Neoplasm inhibitors (yoshidasarcoma, glycylglycine platinum complex) peptide platinum chloride complex bactericide glycylglycine platinum complex carcinostat glycylglycine platinum complex
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17624
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