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Studies on the distribution of platinum in tumor-bearing rats after the administration of platinum co-ordination complexes used in cancer chemotherapy

Zeisler, R. ; Lux, F. ; Seidenberger, H. ; Schönenberger, Helmut ; Beck, W.



Abstract

After the administration of cis-Pt (gly-gly-OEt)2Cl2 complex [60426-60-0] (80 mg/kg and 0.8 mg/kg) to tumor-bearing rats, instrumental neutron activation anal. showed selective uptake of Pt by the ascitic carcinosarcoma cells and significant retention of Pt by the kidney. These findings confirm the drug's usefulness as an antitumor agent and suggest the possibility of nephrotoxicity.


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