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Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes

Hartmann, Rolf W. ; Buchborn, Helga ; Kranzfelder, Gerhard ; Schönenberger, Helmut ; Bogden, Arthur E.


The syntheses of the meso-1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes [alkyl substituent: CH3 (I) [78682-42-5], C2H5 (II) [71953-72-5], C3H7 (III) [78682-43-6], C4H9 (IV) [78682-44-7], i-C4H9 (V) [78682-45-8], and C5H11 (VI) [78682-46-9]] and of d,l-3,4-bis(3'-hydroxyphenyl)hexane [71953-71-4] are described. In vitro these compds. inhibited the 3H-labeled estradiol [50-28-2] receptor interaction ...


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