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Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat

Schönenberger, Helmut ; Kranzfelder, G. ; Schneider, M.


3,4-di(3'-hydroxyphenyl)-hexane (I) [68266-24-0], 3,3'-dihydroxy-alpha ,beta -diethylstilbene (II) [80149-87-7], 3,4-epoxy-3,4-di(4'-hydroxyphenyl)-hexane (III) [6052-82-0], and 3,4-epoxy-3,4-di(3'-hydroxyphenyl)-hexane (IV) [80149-95-7] all inhibited DMBA [57-97-6]-induced, hormone-dependent, mammary carcinoma in rats. I was also prophylactic against DMBA induction of mammary carcinoma. ...


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