Metal complexes with biologically important ligands. XXI. Antitumor active cis-platinum(II) complexes with alpha -amino acid esters and peptide esters. Structure of cis-dichlorobis(glycylglycine ethyl ester)platinum(II)

Beck, Wolfgang ; Bissinger, Herbert ; Girnth-Weller, Michael ; Purucker, Bernhard ; Thiel, Gerhard ; Zippel, Horst ; Seidenberger, Horst ; Wappes, Beate ; Schönenberger, Helmut

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Details

Item type:	Article
Journal or Publication Title:	Chemische Berichte
Publisher:	Wiley-VCH Verl.
Volume:	115
Number of Issue or Book Chapter:	6
Page Range:	pp. 2256-2270
Date:	1982
Additional Information (public):	CAN 97:155280 78-7 Inorganic Chemicals and Reactions 60426-60-0P Role: PRP (Properties), SPN (Synthetic preparation), PREP (Preparation) (prepn. and crystal structure of); 60399-28-2P; 82474-52-0P; 82474-53-1P; 82474-54-2P; 82474-55-3P; 82474-56-4P; 82474-57-5P; 82474-58-6P; 82474-59-7P; 82474-60-0P; 82474-61-1P; 82474-62-2P; 82474-63-3P; 82474-64-4P; 82482-19-7P; 82484-32-0P; 82484-33-1P; 82484-34-2P; 82510-10-9P; 82510-11-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 60426-61-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with amino acid Et ester); 17567-45-2 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with amino acid Et esters); 30729-26-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with ethanol); 64-17-5 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with cis-bis(alpha -amino acid)platinum); 627-74-7; 4117-31-1 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with cis-dichlorobis(p-nitrophenyl glycinate)platinum)
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:	SFB 234
Identification Number:	Value Type 1982:555280 Other
Keywords:	structure platinum ethyl glycylglycinate chloro platinum peptide amino acid ester
Dewey Decimal Classification:	500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	17632

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Abstract

cis-PtX2L2 (X = Cl, Br, I; L = alpha -amino acid ester, peptide ester) and cis-PtZL2 (H2Z = oxalic acid, malonic acid) were prepd. from PtX42- or PtZ22- and L. The dipeptide complexes were also prepd. via peptide synthesis from PtCl2(NH2CHRCO2H)2 and alpha -amino acid esters using carbodiimide as the coupling agent. PtCl2L2 (L = alpha -amino acid ester) were prepd. from cis-Pt(NH2CHRCO)2 and alc. ...

Abstract

cis-PtX2L2 (X = Cl, Br, I; L = alpha -amino acid ester, peptide ester) and cis-PtZL2 (H2Z = oxalic acid, malonic acid) were prepd. from PtX42- or PtZ22- and L. The dipeptide complexes were also prepd. via peptide synthesis from PtCl2(NH2CHRCO2H)2 and alpha -amino acid esters using carbodiimide as the coupling agent. PtCl2L2 (L = alpha -amino acid ester) were prepd. from cis-Pt(NH2CHRCO)2 and alc. in the presence of HCl. cis-PtCl(GlyGlyOET)2 is triclinic, space group P.hivin.1, with a 887.2(2), b 928.2(3), c 1421.2(5) pm, alpha 78.01(3), beta 82.58(3), gamma 60.24(2) Deg, Z = 2, d. (x-ray) = 1.96.

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