Hartmann, R. W., Schönenberger, Helmut and Wrobel, K. H. (1982) 3,4-Bis(3'-hydroxyphenyl)hexane - a new mammary tumor-inhibiting compound. Studies on the mechanism of action on the DMBA-induced, hormone-dependent mammary tumor of the rat. Journal of cancer research and clinical oncology 103 (3), pp. 241-254.
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Abstract
The mechanism of the antitumor activity of 3,4-bis(3'-hydroxyphenyl)hexane (I) [71953-72-5] was studied in rats with DMBA-induced mammary tumors. Changes in the tumor enzyme levels and histol. characteristics during I treatment were examd. and compared with those induced by hexestrol, tamoxifen, and ovariectomy. It was not possible to conclude whether the estrogenic or antiestrogenic activity of I was responsible for its antitumor activity.
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 1982 | ||||
| Additional Information (public): | CAN 97:138268 1-6 Pharmacology 71953-72-5 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, antiestrogenic and estrogenic activity in relation to) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Projects: | SFB 234 | ||||
| Identification Number: |
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| Keywords: | Neoplasm inhibitors (bis(hydroxyphenyl)hexane as, mechanism of, antiestrogenic and estrogenic activity in relation to) Estrogens Role: BIOL (Biological study) (neoplasm inhibition by bis(hydroxyphenyl)hexane in relation to) hydroxyphenylhexane antitumor mechanism | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 17633 |
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