3,4-Bis(3'-hydroxyphenyl)hexane - a new mammary tumor-inhibiting compound. Studies on the mechanism of action on the DMBA-induced, hormone-dependent mammary tumor of the rat

Abstract

The mechanism of the antitumor activity of 3,4-bis(3'-hydroxyphenyl)hexane (I) [71953-72-5] was studied in rats with DMBA-induced mammary tumors. Changes in the tumor enzyme levels and histol. characteristics during I treatment were examd. and compared with those induced by hexestrol, tamoxifen, and ovariectomy. It was not possible to conclude whether the estrogenic or antiestrogenic activity of I was responsible for its antitumor activity.