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cis-Dichloroamino acid platinum(II) complexes

Schönenberger, Helmut ; Bissinger, Herbert ; Thiel, Gerhard ; Zippel, Horst ; Beck, Wolfgang


Cytostatic Cl2Pt(NH2CHRCO2R1)2 (I) (R = H or a group derived from biol. acceptable amino acids and R1 = C>2 alkyl or hydroxy-substituted group) with low toxicity and a strong antitumor effect are prepd. by reaction of II with alcs. (R1OH) and HCl or by treatment of K2PtCl4 with amino acid ester hydrochlorides. The in vitro ED50 of I (R = H, R1 = Et) [82474-52-0], I (R = H, R1 = Bu) [82474-53-1], ...


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