Go to content
UR Home

cis-Dichloroamino acid platinum(II) complexes

Schönenberger, Helmut, Bissinger, Herbert, Thiel, Gerhard, Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

Full text not available from this repository.


Cytostatic Cl2Pt(NH2CHRCO2R1)2 (I) (R = H or a group derived from biol. acceptable amino acids and R1 = C>2 alkyl or hydroxy-substituted group) with low toxicity and a strong antitumor effect are prepd. by reaction of II with alcs. (R1OH) and HCl or by treatment of K2PtCl4 with amino acid ester hydrochlorides. The in vitro ED50 of I (R = H, R1 = Et) [82474-52-0], I (R = H, R1 = Bu) [82474-53-1], ...


Export bibliographical data

Item type:Patent
Additional Information (public):CAN 99:33119 1-6 Pharmacology Patent 19830203 82474-52-0P; 82474-53-1P; 82474-54-2P; 82474-55-3P; 82474-56-4P; 86293-63-2P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 14592-69-9 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with alcs. and hydrochloric acid, cis-platinum complexes from); 10025-99-7 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with amino acid esters) A1
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
81-3128144 3128144Other
Keywords:Amino acids Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (alkyl esters, dichloroplatinum complexes, prepn. and antitumor activity of) Cytotoxic agents Neoplasm inhibitors (dichloro(amino acid)platinum complexes) Alcohols Role: RCT (Reactant), RACT (Reactant or reagent) (aliph., reaction of, with amino acid platinum complexes in hydrochloric acid presence) chloro amino acid platinum cytostatic
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17640
Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons