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Development of selectively acting platinum complexes

Schönenberger, Helmut ; Wappes, Beate ; Jennerwein, Margaretha ; Berger, Martin


The antitumor activity of the stereoisomers of dichloro-1,2-bis(4-hydroxyphenyl)ethylenediamineplatinum (I) was studied in vitro (on ADJ/PC6 plasmacytoma and MDA breast cancer cells) as well as in vivo (in mice bearing ADJ/PC6 plasmacytoma). Whereas (-)-I [91326-62-4] was highly active both in vivo and in vitro, the other isomers were less active; the meso isomer [91265-66-6] was more or less ...


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