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Development of selectively acting platinum complexes

Schönenberger, Helmut, Wappes, Beate, Jennerwein, Margaretha and Berger, Martin (1984) Development of selectively acting platinum complexes. Cancer treatment reviews 11 (Suppl.), pp. 125-130.

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The antitumor activity of the stereoisomers of dichloro-1,2-bis(4-hydroxyphenyl)ethylenediamineplatinum (I) was studied in vitro (on ADJ/PC6 plasmacytoma and MDA breast cancer cells) as well as in vivo (in mice bearing ADJ/PC6 plasmacytoma). Whereas (-)-I [91326-62-4] was highly active both in vivo and in vitro, the other isomers were less active; the meso isomer [91265-66-6] was more or less ...


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Item type:Article
Additional Information (public):CAN 104:215 1-3 Pharmacology 91265-66-6; 91326-62-4; 91326-63-5 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (neoplasm-inhibitory activity of); 91326-61-3 Role: BIOL (Biological study) (neoplasm-inhibitory activity of racemic)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
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Keywords:Neoplasm inhibitors (dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers, structure in relation to) Molecular structure-biological activity relationship (neoplasm-inhibiting, of dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers) ethylenediamineplatinum antitumor structure activity platinum complex antitumor structure activity
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17648
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