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cis-Dichloro[bis(oligopeptide ester)]platinum(II) complexes, study on the detection of antitumor activity with bacteriological test systems

Seidenberger, Horst ; Schönenberger, Helmut ; Beck, Wolfgang ; Girnth-Weller, Michael ; Ruckdeschel, Gotthard


Sixteen title compds., PtA2Cl2 (A = peptide ester groups), and 10 known antitumor compds. were compared in 3 bacteriol. tests: filament induction in Escherichia coli B, growth inhibition of DNA polymerase-deficient E. coli p 3478 pol A-, and prophage induction in E. coli K12 (l). The compds. were also tested for inhibition of ADJ/PC6 plasmacytoma growth in vitro. Only the prophage induction test ...


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