Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids

Abstract

The title complexes I (R = CH2Ph, CHMe2, CH2CHMe2, CHMeEt, (CH2)2SMe) were prepd. from substituted L-1,2-diaminoethanes derived from L-alpha -amino acids and tested for antitumor activity in vitro. I inhibited DNA formation in hormone independent human mammary carcinoma cell line MDA-MB 231.