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Acetoxy-substituted 1,1,2-triphenylbut-1-enes with antiestrogenic and mammary tumor inhibiting properties

Schneider, Martin R. ; Ball, Hartwig ; Schönenberger, Helmut



Abstract

1,1,2-Triphenylbut-1-enes I (R, R1, and R2 are H, OAc) which are substituted with one p- and one m-acetoxy group in two different arom. rings, were synthesized. The (E) and (Z) isomers were isolated, and their identity was established by 1H NMR spectroscopy. Among the tested compds., (E)- and (Z)-1-(3-acetoxyphenyl)-1-(4-acetoxyphenyl)-2-phenylbut-1-enes [(E)-I and (Z)-I] and ...

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