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Synthesis and in vitro antitumor activity of dichloroplatinum complexes of pyridine- and quinoline-amine and -imine ligands and of carbocyclic ethylenediamine ligands

Brunner, Henri ; Schmidt, Manfred ; Schönenberger, Helmut


PtCl2L (L = pyridine- and quinoline-amines and -imines and carbocyclic ethylenediamines) were prepd. and characterized. Their antitumor activity was tested with respect to the hormone independent human mammary carcinoma cell line MDA-MB 231. The inhibition of the cell proliferation and the [3H]-thymidine incorporation was measured. Depending on the substituent patterns, the activities of the ...


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