Synthesis and in vitro antitumor activity of dichloroplatinum complexes of pyridine- and quinoline-amine and -imine ligands and of carbocyclic ethylenediamine ligands

Brunner, Henri ; Schmidt, Manfred ; Schönenberger, Helmut

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Item type:

Article

Journal or Publication Title:

Inorganica chimica acta

Publisher:

Elsevier

Volume:

123

Number of Issue or Book Chapter:

Page Range:

pp. 201-207

Date:

1986

Additional Information (public):

CAN 105:144893 78-7 Inorganic Chemicals and Reactions 58669-32-2; 103382-85-0; 103410-86-2 Role: PRP (Properties) (NMR of); 74139-38-1; 103601-51-0; 103601-52-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antitumor activity of); 64174-32-9P; 78004-69-0P; 103601-38-3P; 103601-39-4P; 103601-40-7P; 103601-41-8P; 103601-42-9P; 103601-44-1P; 103601-45-2P; 103601-46-3P; 103601-47-4P; 103601-48-5P; 103601-49-6P; 104002-67-7P; 104002-68-8P; 104002-69-9P; 104372-25-0P; 104372-26-1P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 4329-81-1P; 18081-89-5P; 90472-36-9P; 103382-80-5P; 103382-81-6P; 103382-82-7P; 103382-83-8P; 103382-84-9P; 103601-37-2P; 104380-70-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 103601-43-0P; 103601-50-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn., antitumor activity and reaction of, with silver nitrate and hydroxymalonic acid); 10025-99-7 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with pyridylalkyleneamines and pyridylalkylamines and quinolylalkylamines)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger

Projects:

SFB 234

Identification Number:

Value	Type
1986:544893	Other

Keywords:

Neoplasm inhibitors (platinum chloro complexes with pyridylalkyleneamines and pyridylalkylamines and quinolylalkylamines as) platinum diamine prepn antitumor activity pyridylalkyleneamine platinum chloro pyridylalkylamine platinum chloro quinolylalkylamine platinum chloro

Dewey Decimal Classification:

500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Item ID:

17655

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Abstract

PtCl2L (L = pyridine- and quinoline-amines and -imines and carbocyclic ethylenediamines) were prepd. and characterized. Their antitumor activity was tested with respect to the hormone independent human mammary carcinoma cell line MDA-MB 231. The inhibition of the cell proliferation and the [3H]-thymidine incorporation was measured. Depending on the substituent patterns, the activities of the ...

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