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Design of metallocenic drugs

Engel, J., Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

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Studies on structure-activity relationships of organometallic anticancer drugs are reviewed. Three methods for the development of new structures are described. Drug targeting: platinum complexes with oestrophilic ligands were synthesized, and the endocrine and cytostatic effects are discussed. Quantitative structure-activity relationship determination is presented as a rational method for the ...


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Item type:Article
Additional Information (public):France
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
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Keywords:Animals *Antineoplastic Agents Cell Division: DE, drug effects Cell Line Leukemia L1210: DT, drug therapy Mammary Neoplasms, Experimental: DT, drug therapy Mice *Neoplasms, Experimental: DT, drug therapy *Organometallic Compounds: TU, therapeutic use Receptors, Estrogen: ME, metabolism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organometallic Compounds) 0 (Receptors, Estrogen)
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17657
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