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Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes

Hartmann, Rolf W. ; Heindl, Alexander ; Schneider, Martin R. ; Schönenberger, Helmut



Abstract

trans-Bis(trifluoromethyl)ethenes I (R = 3-HO, 4-HO) were prepd. by reductive coupling (TiCl4/Zn/pyridine) of the methoxy-substituted alpha ,alpha ,alpha -trifluoroacetophenones, sepn. of the resulting cis- and trans-stilbene derivs., and ether cleavage with BBr3. The cis-stilbenes were catalytically hydrogenated to give meso-hexafluoro-2,3-bis(hydroxyphenyl)butanes II (R = 3-HO, 4-HO). I and II ...

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