Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them
Patent
Schönenberger, Helmut, Hartmann, Rolf, Schneider, Martin, Schwarz, Walter and Engel, Juergen (1986) Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them.Alternative links to fulltext
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Details
| Item type | Patent | ||||||
| Number of Pages | 25 | ||||||
| Date | 1986 | ||||||
| Date of publication | 15 Nov 2010 14:58 | ||||||
| Additional Information (public) | CAN 107:121081 63-6 Pharmaceuticals Patent 19861211 74457-86-6 (2-Fluoro-4-methoxyacetophenone) Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reaction of, with Me iodide); 4124-30-5 (Dichloroacetic anhydride) Role: RCT (Reactant), RACT (Reactant or reagent) (esterification by, of bis(fluorohydroxyphenyl)tetramethylethane); 96826-32-3P Role: RCT (Reactant), PREP (Preparation), RACT (Reactant or reagent) (prepn. and de-O-methylation of); 96826-25-4P (2-(2-Fluoro-4-methoxyphenyl)-2-propanol) Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reductive coupling of); 96826-17-4P; 110300-86-2P; 110300-87-3P; 110300-88-4P; 110300-89-5P Role: THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. of, as neoplasm inhibitor); 506-68-3 (Bromocyan) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with bis(fluorohydroxyphenyl)tetramethylethane) A1 DE 85-3520622 19850608 | ||||||
| Institutions | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||||
| Identification Number |
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| Keywords | Neoplasm inhibitors (tetramethylbis(fluorohydroxyphenyl)ethane derivs., for estrogen receptor-pos. tumors) Prostate gland (disease, benign hyperplasia, treatment of, tetramethylbis(fluorohydroxyphenyl)ethane for) Mammary gland Prostate gland (neoplasm, treatment of, tetramethylbis(fluorohydroxyphenyl)ethane for) fluorohydroxyphenylethane prepn neoplasm inhibitor antiestrogen fluorohydroxyphenylethane estrogen inhibitor fluorohydroxyphenylethane | ||||||
| Dewey Decimal Classification | 500 Science > 540 Chemistry & allied sciences | ||||||
| Status | Published | ||||||
| Refereed | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg | Yes | ||||||
| Item ID | 17659 |
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