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Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them

Schönenberger, Helmut ; Hartmann, Rolf ; Schneider, Martin ; Schwarz, Walter ; Engel, Juergen



Abstract

The title compds. [I; R1, R2 = H, (di)(alkyl)aminocarbonyl, PO(OH)2, (halo)alkanoyl, alkenoyl] are prepd. as antiestrogens, and are useful for the treatment of estrogen receptor-pos. tumors (no data). Thus, 2-(2-fluoro-4-methoxyphenyl)-2-propanol (II; prepn. given) was stirred with TiCl3 in dry dimethoxyethane, followed by the addn. of LiAlH4 and more II, to give I (R1 = R2 = OMe), which was ...

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