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Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes

Jennerwein, M., Wappes, B., Gust, Ronald, Schönenberger, Helmut, Engel, J., Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

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Abstract

Diastereomeric para-substituted dichloro(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most active.


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Item type:Article
Date:1988
Additional Information (public):GERMANY, WEST: Germany, Federal Republic of
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1988315108Other
Keywords:Animals *Antineoplastic Agents: PD, pharmacology Breast Neoplasms: PA, pathology Carcinoma, Ehrlich Tumor: PA, pathology Cell Line Drug Screening Assays, Antitumor Humans Leukemia P388: PA, pathology *Organoplatinum Compounds: TU, therapeutic use Stereoisomerism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organoplatinum Compounds)
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17667
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