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Antitumor activity of o-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes and their methyl ethers

Karl, Johann ; Schönenberger, Helmut


PtCl2L (L = 1,2-bis(2-R-substituted)-4-methoxyphenyl)ethylenediamine) were prepd. from K2PtCl4 and L in the presence of tert-BuOH. Their effects on the human, hormone-independent MDA-MB 231 breast cancer cell line and on the lymphocytic leukemia P 388 of the mouse is compared with that of PtCl2L1 (L1 = 1,2-bis(2-R-substituted)-4-hydroxyphenyl)ethylenediamine). PtCl2L1 are more active on both tumor models than PtCl2L but are less active than cisplatin.

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