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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Inorganica chimica acta | ||||
| Publisher: | Elsevier | ||||
| Volume: | 156 | ||||
| Number of Issue or Book Chapter: | 2 | ||||
| Page Range: | pp. 291-301 | ||||
| Date: | 1989 | ||||
| Additional Information (public): | CAN 111:16657 78-7 Inorganic Chemicals and Reactions 6505-37-9 (2,6-Dichloro-3-methoxybenzaldehyde); 19447-00-8 (2,6-Dimethyl-4-methoxybenzaldehyde); 53039-48-8; 61000-21-3 (2,6-Dimethyl-4-methoxybenzyl alcohol); 121020-64-2 Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reactions of, in prepn. of pyridylmethylamine ligands); 100-70-9 (2-Cyanopyridine) Role: RCT (Reactant), RACT (Reactant or reagent) (Grignard reactions of, pyridylmethylamine ligands by); 10294-33-4 (Boron tribromide); 10294-34-5 (Boron trichloride) Role: RCT (Reactant), RACT (Reactant or reagent) (deprotection by, of methoxy derivs. of pyridylmethylamines); 121131-35-9P; 121131-36-0P; 121131-37-1P; 121131-38-2P; 121131-39-3P; 121131-42-8P; 121131-43-9P; 121131-44-0P; 121131-45-1P; 121131-46-2P; 121131-47-3P; 121131-48-4P; 121131-49-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity of racemic, against hormone-dependent mammary carcinoma); 121131-40-6P; 121131-41-7P Role: PRP (Properties), SPN (Synthetic preparation), PREP (Preparation) (prepn. and activity of, against hormone-dependent mammary carcinoma); 58088-48-5P; 121020-52-8P; 121020-53-9P; 121020-54-0P; 121020-55-1P; 121020-56-2P; 121020-57-3P; 121020-58-4P; 121020-59-5P; 121020-60-8P; 121020-61-9P; 121020-62-0P; 121020-63-1P; 121037-14-7P; 121037-15-8P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and deprotection of); 91-02-1P; 6305-18-6P; 27049-45-2P; 121020-34-6P; 121020-35-7P; 121020-36-8P; 121020-37-9P; 121020-38-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with hydroxylamine hydrochloride, pyridylmethylamine ligand by); 1826-28-4P; 2116-73-6P; 58088-15-6P; 121020-39-1P; 121020-40-4P; 121020-41-5P; 121020-42-6P; 121020-43-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, by zinc, pyridylmethylamine ligand by); 121020-44-8P; 121020-45-9P; 121020-46-0P; 121020-47-1P; 121020-48-2P; 121020-49-3P; 121020-50-6P; 121037-13-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of, pyridylmethylamine deriv. by); 121020-19-7P; 121020-20-0P; 121020-21-1P; 121020-22-2P; 121020-23-3P; 121020-24-4P; 121020-25-5P; 121020-26-6P; 121020-27-7P; 121020-28-8P; 121020-29-9P; 121020-30-2P; 121020-31-3P; 121020-32-4P; 121020-33-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 2746-25-0; 61000-22-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with pyridyltrimethylsiloxyacetonitrile in prepn. of pyridylmethylamines); 71189-77-0 (2-Pyridyltrimethylsiloxyacetonitrile) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with benzyl bromides in prepn. of pyridylmethylamines); 5470-11-1 (Hydroxylamine hydrochloride) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with pyridyl ketones followed by redn. in prepn. of pyridylmethylamine ligands); 83-38-5; 123-11-5; 10025-99-7 (Dipotassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with pyridylmethylamines); 7440-66-6 (Zinc) Role: RCT (Reactant), RACT (Reactant or reagent) (redn. by, of pyridylmethyl oximes in prepn. of pyridylmethylamine derivs.); 16853-85-3 (Lithium aluminum hydride); 16940-66-2 (Sodium tetrahydroborate) Role: RCT (Reactant), RACT (Reactant or reagent) (redn. by, of pyridylmethylimines) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Projects: | SFB 234 | ||||
| Identification Number: |
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| Keywords: | Neoplasm inhibitors (lymphocytic leukemia, platinum complexes with pyridylmethylamines) Neoplasm inhibitors (mammary gland carcinoma, platinum complexes with pyridylmethylamines) cytotoxicity platinum pyridylmethylamine complex aminepyridylmethyl platinum complex | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 17672 |
Abstract
Fifteen ligands of the pyridylmethylamine type and their PtCl2 complexes were prepd., characterized and subjected to a screening system for evaluation of a specific activity against the hormone-dependent mammary carcinoma. To test the estrogenic activity of the ligands, the relative binding affinity (RBA, in vitro) and the uterotrophic and antiuterotrophic activities (mouse uterine wt. test, in ...
Abstract
Fifteen ligands of the pyridylmethylamine type and their PtCl2 complexes were prepd., characterized and subjected to a screening system for evaluation of a specific activity against the hormone-dependent mammary carcinoma. To test the estrogenic activity of the ligands, the relative binding affinity (RBA, in vitro) and the uterotrophic and antiuterotrophic activities (mouse uterine wt. test, in vivo) were detd. To study the cytotoxic effects, the PtCl2 complexes were tested in vitro towards the hormone-independent human mammary carcinoma cell line MDA-MB 231 and in vivo towards the lymphocytic P388 leukemia. Finally, there was a comparative test of ligands and PtCl2 complexes in the hormone-independent MXT (3.2) Ovex mammary carcinoma and the hormone-dependent MXT M3.2 mammary carcinoma.
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