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Synthesis of platinum dichloride complexes of pyridylmethylamine ligands and their activity against hormone-dependent mammary carcinoma

Brunner, Henri ; Dafinger, Willi ; Schönenberger, Helmut



Abstract

Fifteen ligands of the pyridylmethylamine type and their PtCl2 complexes were prepd., characterized and subjected to a screening system for evaluation of a specific activity against the hormone-dependent mammary carcinoma. To test the estrogenic activity of the ligands, the relative binding affinity (RBA, in vitro) and the uterotrophic and antiuterotrophic activities (mouse uterine wt. test, in ...

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