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Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-complexes. Part II. Biological properties

Jennerwein, Margaretha ; Gust, Ronald ; Müller, Richard ; Schönenberger, Helmut ; Engel, Juergen ; Berger, Martin R. ; Schmaehl, Dietrich ; Seeber, Siegfried ; Osieka, Reinhardt


The antitumor activity of stereoisomers of the title complex (I) in several tumor models (MDA-MB 231 breast cancer cell line; mouse P 388 leukemia, mouse L 1210 leukemia, rat L 5222 leukemia, and mouse wild-type Ehrlich ascites tumor resistant to cisplatin, etoposide, cyclophosphamide, and daunomycin, resp.) is described. For comparison, the analogous ...


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