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Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-complexes. Part II. Biological properties

Jennerwein, Margaretha, Gust, Ronald, Müller, Richard, Schönenberger, Helmut, Engel, Juergen, Berger, Martin R., Schmaehl, Dietrich, Seeber, Siegfried and Osieka, Reinhardt (1989) Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-complexes. Part II. Biological properties. Archiv der Pharmazie 322 (2), pp. 67-73.

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Abstract

The antitumor activity of stereoisomers of the title complex (I) in several tumor models (MDA-MB 231 breast cancer cell line; mouse P 388 leukemia, mouse L 1210 leukemia, rat L 5222 leukemia, and mouse wild-type Ehrlich ascites tumor resistant to cisplatin, etoposide, cyclophosphamide, and daunomycin, resp.) is described. For comparison, the analogous ...

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Item type:Article
Date:1989
Additional Information (public):CAN 110:147201 1-3 Pharmacology 15663-27-1 (Cisplatin) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (antitumor activity of platinum complex stereoisomers in combination with); 7440-06-4D (Platinum); 91265-66-6; 91326-61-3; 91326-62-4; 91326-63-5; 93856-31-6; 93983-45-0; 119479-53-7; 119479-54-8 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antitumor activity of, stereoselectivity of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
ValueType
1989:147201Other
Keywords:Neoplasm inhibitors ([(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) stereoisomer complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting, of [(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) stereoisomer complexes) platinum complex stereoisomer antitumor structure
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17674
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