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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Archiv der Pharmazie | ||||
| Publisher: | Wiley | ||||
| Volume: | 322 | ||||
| Number of Issue or Book Chapter: | 12 | ||||
| Page Range: | pp. 857-862 | ||||
| Date: | 1989 | ||||
| Additional Information (public): | CAN 112:111625 1-6 Pharmacology 50-67-9 (5-Hydroxytryptamine); 51-61-6 (Dopamine); 51-65-0 (DL-4-Fluorophenylalanine); 51-67-2 (Tyramine); 56-12-2; 60-23-1 (Cysteamine); 61-54-1 (Tryptamine); 62-57-7 (2-Aminoisobutyric acid); 63-84-3 (DL-3,4-Dihydroxyphenylalanine); 64-12-0 (DL-p-Chloroamphetamine); 67-21-0 (DL-Ethionine); 70-78-0 (3-Iodo-L-tyrosine); 103-01-5 (N-Phenylglycine); 104-63-2 (N-Benzylethanolamine); 153-44-6 (beta -Methyl-DL-tryptophan); 153-91-3 (alpha -Methyl-DL-tryptophan); 299-26-3; 403-90-7 (DL-3-Fluorotyrosine); 405-39-0; 443-80-1; 456-88-2 (DL-3-Fluorophenylalanine); 500-44-7; 526-31-8; 536-33-4 (Ethionamide); 541-48-0 (DL-3-Aminobutyric acid); 543-38-4; 552-85-2; 587-20-2 (alpha -Methylhistidine); 621-44-3 (3-Nitro-L-tyrosine); 671-42-1 (DL-alpha -Amino-e-caprolactam); 687-51-4 (L-Leucinamide); 760-78-1 (DL-Norvaline); 951-55-3 (5-Methyl-DL-tryptophan); 979-92-0 (S-Adenosyl-L-homocysteine); 1113-41-3 (L-Penicillamine); 1132-26-9 (alpha -Methyl-DL-phenylalanine); 1138-80-3; 1149-26-4; 1464-42-2 (Seleno-DL-methionine); 1483-07-4 (Albizziin); 1955-68-6; 2021-58-1 (beta -2-Thienyl-DL-alanine); 2133-34-8 (L-Azetidine-2-carboxylic acid); 2260-12-0 (beta -Methyl-DL-phenylalanine); 2280-42-4 (DL-beta -Hydroxynorvaline); 2629-55-2 (DL-2-Fluorophenylalanine); 2697-61-2 (Selenocystamine); 2731-73-9 (L-beta -Chloroalanine); 2749-07-7 (alpha -Methyl-DL-methionine); 2792-72-5; 2799-07-7 (S-Trityl-L-cysteine); 2897-21-4 (DL-Selenocystine); 2899-37-8 (L-Methioninol); 2935-35-5 (L-alpha -Phenylglycine); 2936-69-8 (L-4-Thialysine); 3182-95-4 (L-Phenylalaninol); 3251-08-9; 3395-35-5 (DL-3,4-Dehydroproline); 3647-71-0 (N-Benzyl-2-phenylethylamine); 4144-02-9; 4350-09-8 (L-5-Hydroxytryptophan); 4746-36-5 (DL-4-Azaleucine); 4836-52-6 (L-Histidinol); 5034-68-4 (L-Tyrosinol); 6232-19-5 (beta -Cyano-L-alanine); 6645-45-0; 6829-40-9 (Aminomalonic acid diethyl ester); 7303-50-6 (DL-7-Azatryptophan); 7533-40-6 (L-Leucinol); 7695-56-9 (DL-threo-beta -Phenylserine); 7730-20-3 (DL-6-Fluorotryptophan); 10065-72-2 (L-Alanine methyl ester); 13004-62-1 (trans-2,6-Diaminohex-4-enoic acid); 14954-40-6; 16063-80-2; 16120-92-6; 16748-73-5 (L-Aspartic acid diamide); 17332-70-6 (7-Methyl-DL-tryptophan); 17463-43-3 (3,3,3-Trifluoro-DL-alanine); 17480-69-2 (N-Benzyl-D-amphetamine); 17781-05-4; 18625-03-1; 18865-31-1; 19461-04-2 (N-Benzyl-L-phenylalanine); 23220-52-2 (meso-2,3-Diaminosuccinic acid); 24629-25-2; 25125-92-2; 25631-05-4 (DL-4-Fluorotryptophan); 26340-83-0; 26988-72-7 (1-Methyl-DL-tryptophan); 28057-52-5 (L-Isoasparagine); 28143-91-1; 34592-47-7; 40172-05-2; 52153-41-0; 54542-13-1; 55779-32-3; 57601-68-0; 57734-57-3 (2-Aminomethylpyrrolidine); 60046-47-1; 65934-95-4 (Fenitropan); 75543-73-6; 80300-21-6; 80300-23-8; 91531-30-5 (Antineoplaston A10); 108321-88-6; 124081-74-9; 125293-76-7; 125293-77-8; 125293-79-0 (DL-2,6-Diphthalimidocaproic acid methyl ester); 125293-80-3; 125293-81-4; 125293-82-5; 125293-83-6; 125293-85-8; 125293-86-9; 125356-75-4; 125729-28-4 Role: BIOL (Biological study) (amino acid antagonist, aminoacyl tRNA synthetase inhibitory and antileukemic activities of); 52-90-4 (Cysteine); 56-40-6 (Glycine); 56-41-7 (L-Alanine); 56-84-8 (Aspartic acid); 56-85-9 (Glutamine); 56-86-0 (Glutamic acid); 70-47-3 (Asparagine); 71-00-1 (Histidine); 73-32-5 (Isoleucine); 74-79-3 (L-Arginine) Role: BIOL (Biological study) (antagonists, aminoacyl tRNA synthetase inhibitory and antileukemic activities of); 56-45-1 (L-Serine); 56-87-1 (L-Lysine); 60-18-4 (L-Tyrosine); 61-90-5 (L-Leucine); 63-68-3 (L-Methionine); 63-91-2 (L-Phenylalanine); 72-18-4 (L-Valine); 72-19-5 (L-Threonine); 147-85-3 (L-Proline) Role: BIOL (Biological study) (antagonists, aminoacyl-tRNA synthetase and antileukemia activities of); 9028-02-8 (Aminoacyl tRNA synthetase) Role: PROC (Process) (inhibition of, by amino acid antagonist, antileukemia activities of) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Projects: | SFB 234 | ||||
| Identification Number: |
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| Keywords: | Amino acids Role: BIOL (Biological study) (antagonists, aminoacyl tRNA synthetase inhibitory and antileukemic activities of) Neoplasm inhibitors (leukemia, amino acid antagonists as, aminoacyl tRNA synthetase inhibition in relation to) amino acid antagonist antiproliferation tRNA synthetase | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 17675 |
Abstract
Amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were tested for their antiproliferative effect against the murine leukemic cell line P338D1. Micromolar concns. of the compds. S-tritylcysteine, fenitropan, and beta -chloroalanine were markedly inhibitory. In the mouse only S-tritylcysteine was effective against leukemia P388 (T/C = 211%). The ...
Abstract
Amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were tested for their antiproliferative effect against the murine leukemic cell line P338D1. Micromolar concns. of the compds. S-tritylcysteine, fenitropan, and beta -chloroalanine were markedly inhibitory. In the mouse only S-tritylcysteine was effective against leukemia P388 (T/C = 211%). The inhibitory effect on aminoacyl-tRNA synthetases and the antiproliferative action on P388D1 or P388 could not be correlated.
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