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Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer

Porzsolt, F. ; Otto, A. M. ; Trauschel, B. ; Buck, C. ; Wawer, A. W. ; Schönenberger, Helmut


Several investigators have discussed the possible combination of tamoxifen and interferon (IFN) in the treatment of breast cancer patients. The rationale in combining these drugs is that IFN induces the expression of estrogen receptors and therefore increases the sensitivity of breast cancer cells toward the growth-inhibitory activity of tamoxifen. In this paper we review the literature on the ...


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