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Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer

Porzsolt, F., Otto, A. M., Trauschel, B., Buck, C., Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

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Several investigators have discussed the possible combination of tamoxifen and interferon (IFN) in the treatment of breast cancer patients. The rationale in combining these drugs is that IFN induces the expression of estrogen receptors and therefore increases the sensitivity of breast cancer cells toward the growth-inhibitory activity of tamoxifen. In this paper we review the literature on the ...


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Item type:Article
Additional Information (public):GERMANY, WEST: Germany, Federal Republic of 10540-29-1 (Tamoxifen); 9008-11-1 (Interferons)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
Identification Number:
Keywords:Antineoplastic Combined Chemotherapy Protocols: PD, pharmacology *Antineoplastic Combined Chemotherapy Protocols: TU, therapeutic use Breast Neoplasms: AN, analysis *Breast Neoplasms: DT, drug therapy Breast Neoplasms: PA, pathology Humans *Interferons: AD, administration & dosage Receptors, Estrogen: AN, analysis *Tamoxifen: AD, administration & dosage Tumor Cells, Cultured: DE, drug effects 0 (Receptors, Estrogen)
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17676
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