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[1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): an endocrine-active platinum complex with a specific prostatic tumor-inhibiting activity

Schneider, M. R. ; Schiller, C. D. ; Humm, A. ; Spruss, T. ; Schönenberger, Helmut ; Amselgruber, W. ; Sinowatz, F.



Abstract

[1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethlenediamine]dichloroplatinum(II), (I) a Pt complex with endocrine activity and a specific effect on hormone-dependent mammary tumors, was tested for its tumor-inhibitory activity in the hormone-sensitive R 3327 and Nb prostate carcinoma models of the rat and for its endocrine activities in comparison to the ligand L (the non-Pt part of the drug) and ...

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