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[1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): an endocrine-active platinum complex with a specific prostatic tumor-inhibiting activity

Schneider, M. R., Schiller, C. D., Humm, A., Spruss, T., Schönenberger, Helmut, Amselgruber, W. and Sinowatz, F. (1989) [1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): an endocrine-active platinum complex with a specific prostatic tumor-inhibiting activity. The prostate 15 (2), pp. 135-148.

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[1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethlenediamine]dichloroplatinum(II), (I) a Pt complex with endocrine activity and a specific effect on hormone-dependent mammary tumors, was tested for its tumor-inhibitory activity in the hormone-sensitive R 3327 and Nb prostate carcinoma models of the rat and for its endocrine activities in comparison to the ligand L (the non-Pt part of the drug) and ...


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Item type:Article
Additional Information (public):CAN 112:48357 1-6 Pharmacology 58-22-0 (Testosterone) Role: BIOL (Biological study) (decrease of, by platinum compd., prostate carcinoma inhibition from); 117773-99-6 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, in prostate gland)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
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Keywords:Neoplasm inhibitors (carcinoma, platinum compd. as, in prostate) Prostate gland (neoplasm, carcinoma, inhibition of, by platinum compds.) dichlorohydroxyphenylethylenediaminedichlorplatinum antitumor prostate platinum compd antitumor prostate
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17677
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