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Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands

Brunner, Henri ; Hankofer, Peter ; Holzinger, Ulrich ; Treittinger, Barbara ; Schönenberger, Helmut


The prepn. of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described. The new compds. were tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the ...


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