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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | European journal of medicinal chemistry. | ||||
| Publisher: | EDIFOR | ||||
| Volume: | 25 | ||||
| Number of Issue or Book Chapter: | 1 | ||||
| Page Range: | pp. 35-44 | ||||
| Date: | 1990 | ||||
| Additional Information (public): | CAN 113:107966 78-7 Inorganic Chemicals and Reactions 51-31-0; 2627-86-3 Role: RCT (Reactant), RACT (Reactant or reagent) (amidation by, of benzyloxycarbonylphenylalanine); 3588-57-6 Role: RCT (Reactant), RACT (Reactant or reagent) (amidation of, with isopropylamine); 29622-19-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and amidation of, followed by redn.); 105368-95-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and anionic exchange and antitumor activity of racemic); 72426-83-6P; 102050-52-2P; 105237-00-1P; 105308-31-4P; 105856-64-2P; 105856-65-3P; 105870-24-4P; 128610-09-3P; 128610-10-6P; 128610-12-8P; 128610-14-0P; 128610-15-1P; 128610-16-2P; 128636-07-7P; 128636-08-8P; 128636-09-9P; 128636-10-2P; 128636-11-3P; 128636-13-5P; 128636-14-6P; 128658-76-4P; 128658-77-5P; 128705-27-1P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 105237-01-2P; 105237-02-3P; 105237-03-4P; 105237-04-5P; 105237-05-6P; 105856-39-1P; 105856-40-4P; 105856-49-3P; 105856-52-8P; 105856-54-0P; 105856-55-1P; 105856-56-2P; 105856-57-3P; 105856-58-4P; 105856-59-5P; 105856-61-9P; 105870-25-5P; 128594-51-4P; 128594-52-5P; 128594-53-6P; 128594-54-7P; 128594-55-8P; 128594-56-9P; 128594-57-0P; 128594-58-1P; 128594-59-2P; 128594-60-5P; 128594-61-6P; 128594-62-7P; 128594-63-8P; 128594-69-4P; 128610-20-8P; 128610-21-9P; 128610-23-1P; 128610-24-2P; 128610-25-3P; 128636-06-6P; 128705-23-7P; 128705-24-8P; 128705-25-9P; 128705-26-0P; 128705-28-2P; 128705-29-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and antitumor activity of racemic); 104907-23-5P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and cleavage of); 3321-96-8P; 4441-50-3P; 14108-60-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and esterification of, followed by amidation and redn.); 51-65-0P; 63-91-2P (L-Phenylalanine); 456-88-2P; 673-06-3P (D-Phenylalanine); 1956-15-6P; 2629-55-2P; 2835-06-5P; 4599-47-7P; 5472-67-3P; 5472-68-4P; 5472-70-8P; 7635-29-2P; 14091-08-8P; 14091-11-3P; 14091-16-8P; 14173-39-8P; 21176-60-3P; 23633-07-0P; 28095-56-9P; 32133-35-0P; 32133-36-1P; 33522-63-3P; 34993-02-7P; 76985-08-5P; 80997-87-1P; 94294-08-3P; 108540-72-3P; 128833-94-3P; 128833-95-4P; 128833-96-5P; 128833-97-6P; 128833-98-7P; 128833-99-8P; 128834-00-4P; 128834-01-5P; 128834-02-6P; 128834-03-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and esterification of, followed by amidation and redn. of); 75543-73-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with acetone); 128834-07-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with hydrogen bromide and redn. of); 55857-61-9P; 60058-40-4P; 68319-33-5P; 81375-37-3P; 108945-12-6P; 128834-04-8P; 128834-05-9P; 128834-06-0P; 128834-08-2P; 128834-09-3P; 128834-10-6P; 128834-11-7P; 128834-12-8P; 128900-00-5P; 128900-01-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and redn. of); 29802-24-2P; 85612-59-5P; 85612-60-8P; 104907-19-9P; 104907-20-2P; 104907-21-3P; 104907-22-4P; 104936-00-7P; 104975-45-3P; 105237-15-8P; 105469-09-8P; 125293-80-3P; 128636-12-4P; 128833-58-9P; 128833-59-0P; 128833-60-3P; 128833-61-4P; 128833-62-5P; 128833-64-7P; 128833-65-8P; 128833-66-9P; 128833-67-0P; 128833-68-1P; 128833-69-2P; 128833-70-5P; 128833-71-6P; 128833-72-7P; 128833-73-8P; 128833-74-9P; 128833-75-0P; 128833-76-1P; 128833-77-2P; 128833-78-3P; 128833-79-4P; 128833-80-7P; 128833-81-8P; 128833-82-9P; 128833-83-0P; 128833-84-1P; 128833-85-2P; 128833-86-3P; 128833-87-4P; 128833-89-6P; 128833-90-9P; 128833-91-0P; 128833-92-1P; 128833-93-2P; 28834-13-9P; 128834-14-0P; 128899-90-1P; 128899-91-2P; 128899-92-3P; 128899-93-4P; 128899-94-5P; 128899-95-6P; 128899-96-7P; 128899-97-8P; 128899-98-9P; 128899-99-0P; 128900-02-7P; 128900-03-8P; 176910-85-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 128610-22-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of reacmic); 74-89-5 (Methanamine) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with Me phenylalanine); 17193-31-6 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with formic acid and formaldehyde or acetone); 2577-90-4 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with methylamine); 10025-99-7 (Potassium tetrachloroplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with substituted ethylenediamine); 75768-06-8 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction with hydrogen bromide and redn. of) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Projects: | SFB 234 | ||||
| Identification Number: |
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| Keywords: | Neoplasm inhibitors (platinate chloro substituted-ethylendiamine complexes) Amino acids Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and esterification of, followed by amidation and redn.) platinate chloro substituted ethylenediamine antitumor activity platinate chloro substituted ethylenediamine amino acid esterification amination amino acid ester amide prepn redn | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 17679 |
Abstract
The prepn. of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described. The new compds. were tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the ...
Abstract
The prepn. of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described. The new compds. were tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the CD2F1-mouse. In the P388 test, 53 of the 55 tested complexes fulfill the min. activity of 125% T/C required for a substance to be active.
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