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Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7

Buck, C. ; Wawer, A. ; Mach, W. ; Digel, W. ; Otto, A. M. ; Schönenberger, Helmut ; Porzsolt, F.



Abstract

The effect was studied of recombinant lymphotoxin (rLT) in combination with interferons (rIFN-alpha , huIFN-beta , and rIFN-gamma ) on the proliferation of the breast cancer cell line MCF-7. Spontaneous [3H]thymidine incorporation of MCF-7 cells ranged up to 190,000 cmp after 72 h. The addn. of high doses of rLT (>100 U/mL) caused a significant growth inhibition, whereas low concns. (<20 U/mL) ...

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