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Mammary-tumor-inhibiting properties of (S,S)-[1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)

Spruss, Thilo ; Gust, Ronald ; Müller, Richard ; Engel, Juergen ; Schönenberger, Helmut



Abstract

[(S,S)-1,2-Bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum (II) [(S,S)-I shows a strong and dose-dependent effect on the hormone-dependent MXT mammary carcinoma of the mouse. R,R/S,S-I is markedly less active. Other I analogs were also tested.


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