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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Archiv der Pharmazie | ||||
| Publisher: | Wiley | ||||
| Volume: | 324 | ||||
| Number of Issue or Book Chapter: | 3 | ||||
| Page Range: | pp. 153-160 | ||||
| Date: | 1991 | ||||
| Additional Information (public): | CAN 114:220909 1-6 Pharmacology 50-67-9 (5-Hydroxy-tryptamine); 60-23-1 (Cysteamine); 62-57-7 (2-Aminoisobutyric acid); 500-44-7 (Mimosine); 526-31-8; 1955-68-6; 2697-61-2 (Selenocystamine); 2792-72-5; 2799-07-7 (s-Trityl-L-cysteine); 2897-21-4 (DL-Selenocystine); 2936-69-8 (L-4-Thialysine); 4746-36-5 (DL-4-Azaleucine); 6232-19-5 (beta -Cyano-L-alanine); 6645-45-0; 16748-73-5; 19461-04-2; 25631-05-4 (DL-4-Fluorotryptophan); 26340-83-0; 26988-72-7 (1-Methyl-DL-tryptophan); 34985-37-0 ((S)-2-Methylbutylamine); 57734-57-3 (2-Pyrrolidinemethanamine); 77834-86-7; 80300-21-6; 125293-76-7; 125293-86-9 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antitumor activity of, as excitatory amino acid antagonist); 50-44-2 (6-Mercapto-purine); 50-76-0 (Actinomycin D); 51-21-8 (5-Fluorouracil); 59-05-2 (Methotrexate); 127-07-1 (Hydroxyurea); 147-94-4 (Ara C); 148-82-3; 15663-27-1 (Cisplatin); 105856-26-6 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antitumor activity of, excitatory amino acid antagonists effect on); 9015-68-3 (Asparaginase) Role: BIOL (Biological study) (antitumor activity with excitatory amino acid antagonists); 9028-02-8 (Aminoacyl-tRNA synthetase) Role: PROC (Process) (inhibition of, by excitatory amino acid inhibitors, antitumor activity in relation to) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Projects (Historical): | SFB 234 | ||||
| Identification Number: |
| ||||
| Keywords: | Neoplasm inhibitors (excitatory amino acid antagonists as) Amino acids Role: BIOL (Biological study) (excitatory, antagonists of, antitumor activity of, aminoacyl-tRNA synthetase targeting in) amino acid antagonist aminoacyl synthetase synthetase antitumor amino acid antagonist | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 17687 |
Abstract
The combined effects of amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were investigated on the murine leukemic cell line P388 D1. As the best result a summation of the antiproliferative effects was obsd. Combinations with established cytostatic agents like platinum complexes or other antitumor compds. also yielded partly additive effects. In ...
Abstract
The combined effects of amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were investigated on the murine leukemic cell line P388 D1. As the best result a summation of the antiproliferative effects was obsd. Combinations with established cytostatic agents like platinum complexes or other antitumor compds. also yielded partly additive effects. In expts. performed with asparaginase, L-aspartic acid-beta -hydroxamate gave synergistic growth inhibition of P388 D1 cells in vitro, which was reflected by additive effects against murine leukemia P388 in vivo.
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