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Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part III. Combination experiments

Laske, Reiner ; Schönenberger, Helmut ; Holler, Eggehard



Abstract

The combined effects of amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were investigated on the murine leukemic cell line P388 D1. As the best result a summation of the antiproliferative effects was obsd. Combinations with established cytostatic agents like platinum complexes or other antitumor compds. also yielded partly additive effects. In ...

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