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Tumor inhibiting [1,2-bis(difluorophenyl)ethylenediamine]dichloroplatinum(II) complexes. I. Synthesis

Müller, Richard, Schickaneder, Edith, Jennerwein, Margaretha, Reile, Herta, Spruss, Thilo, Engel, Juergen and Schönenberger, Helmut (1991) Tumor inhibiting [1,2-bis(difluorophenyl)ethylenediamine]dichloroplatinum(II) complexes. I. Synthesis. Archiv der Pharmazie 324 (2), pp. 115-120.

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meso- And DL-[NH2CH(C6H3X2)]2 (L; X2 = 2,3-, 2,4-, 2,5-, 2,6-, 3,4-, 3,5-F2) were prepd. from meso-[NH2CH(C6H4OH)]2 and the resp. benzaldehydes by a diazo-Cope rearrangement. L reacted with K2PtX4 (X = Cl, I) to give PtLCl2 and PtLI2 (X2 = 2,4- and 2,6-F2) and PtLI reacted with Ag2SO4 to give PtL(SO4).

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Item type:Article
Additional Information (public):CAN 114:177255 78-7 Inorganic Chemicals and Reactions 58519-80-5 (meso-1,2-Bis(2-hydroxyphenyl)ethylenediamine) Role: RCT (Reactant), RACT (Reactant or reagent) (condensation reaction of, followed by acid hydrolysis with Cope rearrangement); 437-81-0 (2,6-Difluorobenzaldehyde); 1550-35-2 (2,4-Difluorobenzaldehyde); 2646-90-4 (2,5-Difluorobenzaldehyde); 2646-91-5 (2,3-Difluorobenzaldehyde); 32085-88-4 (3,5-Difluorobenzaldehyde); 34036-07-2 (3,4-Difluorobenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (condensation reaction of, with bis(hydroxyphenyl)ethylenediamine or bis(difluorosalicylidene)diphenylethylenediamine); 133214-25-2P; 133214-26-3P; 133214-27-4P; 133214-28-5P; 133214-29-6P; 133214-30-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and acid hydrolysis and condensation reaction of, with difluorobenzaldehyde); 133008-28-3P; 133008-29-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and reaction of racemic, with silver sulfate); 133214-43-4P; 133214-44-5P; 133214-46-7P; 133214-47-8P; 133253-55-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with hydrochloric acid); 132953-59-4P; 132953-60-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with silver sulfate); 133214-31-0P; 133214-32-1P; 133214-33-2P; 133214-34-3P; 133214-35-4P; 133214-36-5P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and stereoisomerization and acid hydrolysis of); 132936-04-0P; 132936-05-1P; 133007-06-4P; 133007-07-5P; 133007-09-7P; 133007-10-0P; 133007-11-1P; 133098-31-4P; 133214-37-6P; 133214-38-7P; 133214-39-8P; 133214-40-1P; 133214-41-2P; 133214-42-3P; 133214-45-6P; 133214-48-9P; 133214-49-0P; 133214-50-3P; 133214-51-4P; 133214-52-5P; 133214-53-6P; 133214-54-7P; 133214-55-8P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 132936-06-2P; 132936-07-3P; 132936-09-5P; 132936-10-8P; 132936-11-9P; 132936-13-1P; 133006-06-1P; 133006-07-2P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of racemic); 10025-99-7 (Dipotassium tetrachloroplatinate) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with bis(difluorophenyl)ethylenediamine stereoisomers)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
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Keywords:Schiff bases Role: SPN (Synthetic preparation), PREP (Preparation) (bis(difluorosalicylidene)diphenylethylenediamine, prepn. and acid hydrolysis of) Amines Role: SPN (Synthetic preparation), PREP (Preparation) fluorophenylethylenediamine platinum complex ethylenediamine fluorophenyl platinum complex
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17689
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