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Dissociation of estrogenic and cytotoxic properties of an estrogen receptor-binding platinum complex in human breast cancer cell lines

Otto, Angela M. ; Faderl, Michael ; Schönenberger, Helmut



Abstract

The Pt complex [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]diaqua-Pt(II) sulfate (meso-6-PtSO4) was designed with the concept of combining the cytotoxic cisplatin with an estrogen receptor (ER)-binding ligand for targeting to ER+ mammary tumor cells. This Pt complex selectively inhibits growth of ER+ mammary tumors in rodents. To study the cellular mechanisms of action, cultures of ...

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