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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Journal or Publication Title: | Inorganica chimica acta | ||||
| Publisher: | Elsevier | ||||
| Volume: | 195 | ||||
| Number of Issue or Book Chapter: | 1 | ||||
| Page Range: | pp. 77-87 | ||||
| Date: | 1992 | ||||
| Additional Information (public): | CAN 117:203879 78-7 Inorganic Chemicals and Reactions 143988-12-9P Role: PREP (Preparation) (formation of racemic, from bis(fluorophenyl)ethylenediamine sulfato complex in DMSO); 125948-92-7P Role: PREP (Preparation) (formation of racemic, from bis(fluorophenyl)ethylenediamine sulfato complex in aq. soln.); 143988-11-8P; 143989-42-8P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(fluorophenyl)ethylenediamine sulfato complex in DMSO); 61951-01-7P; 62048-57-1P; 143989-39-3P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(fluorophenyl)ethylenediamine sulfato complex in aq. soln.); 143989-43-9P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(fluorophenyl)ethylenediamine sulfopropionato complex in soln.); 143988-09-4P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(hydroxyphenyl)ethylenediamine sulfato complex and chloride); 138258-84-1P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(hydroxyphenyl)ethylenediamine sulfato or sulfopropionato complex and chloride); 143989-46-2P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(hydroxyphenyl)ethylenediamine sulfopropionato complex and chloride); 143989-44-0P; 143989-45-1P; 144012-63-5P; 144012-64-6P Role: FORM (Formation, nonpreparative), PREP (Preparation) (formation of, from bis(hydroxyphenyl)ethylenediamine sulfopropionato complex in soln.); 143982-84-7P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and complexation of, with platinum arylethylenediamine complexes); 143989-38-2P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction of, with sulfopropionate); 143989-40-6P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and soln. chem. and antitumor activity of racemic); 143989-39-3P; 143989-44-0P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (prepn. and soln. chem. and reaction with chloride and antitumor activity of); 125949-84-0 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of racemic, with sulfopropionate); 5961-88-6 (3-Sulfopropionic acid anhydride) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with barium carbonate and silver sulfate); 14708-56-6 (Dipotassium tetraiodoplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with bis(hydroxyphenyl)ethylenediamine); 10294-26-5 (Disilver sulfate) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with sulfopropionic acid anhydride-barium carbonate rx product); 143989-41-7 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), BIOL (Biological study) (soln. chem. and antitumor activity of racemic) | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger | ||||
| Projects (Historical): | SFB 234 | ||||
| Identification Number: |
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| Keywords: | Neoplasm inhibitors (mammary gland carcinoma, platinum sulfato or sulfopropionato complexes with diarylethylenediamines) Mammary gland (neoplasm, carcinoma, inhibitors, platinum sulfato or sulfopropionato complexes with diarylethylenediamines) antitumor agent platinum ethylenediamine sulfopropionato sulfato | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 17694 |
Abstract
The syntheses, solid state and soln. chem., and the in vitro cytotoxic activities of H2O sol. (1,2-diaryl-1,2-ethylenediamine)platinum(II) complexes, having either the sulfato or the novel sulfopropionato anionic leaving group, are described. The compds. were prepd. by allowing the (1,2-diaryl-1,2-ethylenediamine)diiodoplatinum(II) complexes and either Ag2SO4 or Ag sulfopropionate to react in ...
Abstract
The syntheses, solid state and soln. chem., and the in vitro cytotoxic activities of H2O sol. (1,2-diaryl-1,2-ethylenediamine)platinum(II) complexes, having either the sulfato or the novel sulfopropionato anionic leaving group, are described. The compds. were prepd. by allowing the (1,2-diaryl-1,2-ethylenediamine)diiodoplatinum(II) complexes and either Ag2SO4 or Ag sulfopropionate to react in H2O. IR studies of the complexes in the solid state indicate that the prepn. are mixts. of Pt species, whereby the anionic leaving groups show varying forms of Pt coordination. These compns. vary depending on the procedure used to isolate the Pt complexes. The aq. soln. chem. was studied by a reversed-phase HPLC assay. The results of these studies show several Pt species in soln. From the column retention properties of the species and their behavior to changes in pH, these soln. components are various monomers and oligomers of the parent Pt complex. These results are in agreement with previous 195Pt and 15N NMR studies from other diaminePt(II) complexes. The type of arom. substitution has an influence on the qual. compn. of the aq. Pt species; an addnl. Pt species is obsd. in aq. solns. of Pt complexes possessing an ortho phenol group compared to the complexes possessing a para F group. Aq. reactions of the Pt complexes with Cl- indicate that the sulfopropionato ligand is more stable-bound than the SO42- ligand; results from cell culture cytotoxicity tests show little difference between the cytotoxic activities of the complexes possessing a sulfato or a sulfopropionato leaving group.
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