Schertl, Sabine, Gust, Ronald, Müller, Richard, Spruss, Thilo und Schönenberger, Helmut (1992) Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Part III. Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 325 (2), S. 113-118.
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Zusammenfassung
Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes produce a strong configuration-dependent inhibition of the hormone sensitive MXT-mammary carcinoma of the mouse. Besides an interference in DNA synthesis analogous to that of cisplatin, an estrogen level lowering effect is responsible for its antitumor activity. The new complexes also show a significant activity on the hormone-independent MXT-mammary carcinoma of the mouse.
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| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Datum: | 1992 | ||||
| Zusätzliche Informationen (Öffentlich): | CAN 116:187486 1-3 Pharmacology 93856-31-6; 106400-42-4 Role: BIOL (Biological study) (mammary tumor inhibition by racemic, structure in relation to); 93983-45-0; 105856-36-8; 119479-53-7; 119479-54-8 Role: BIOL (Biological study) (mammary tumor inhibition by, structure in relation to) | ||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger | ||||
| Projekte: | SFB 234 | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Neoplasm inhibitors (mammary gland, hydroxyphenylethylenediamineplatinum complexes as, structure-activity relationship of) Mammary gland (neoplasm, inhibitors, hydroxyphenylethylenediamineplatinum complexes as, structure-activity relationship of) Molecular structure-biological activity relationship (neoplasm-inhibiting, of hydroxyphenylethylenediamineplatinum complexes) hydroxyphenyl ethylenediamine platinum mammary tumor inhibitor | ||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Eingebracht am: | 12 Nov 2010 06:54 | ||||
| Zuletzt geändert: | 08 Mrz 2017 08:28 | ||||
| Dokumenten-ID: | 17696 |
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