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Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes

Gust, Ronald ; Schönenberger, Helmut ; Klement, Ulrich ; Range, Klaus Juergen



Abstract

Complete three-dimensional x-ray crystal structure analyses of estrogenic [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]diiodoplatinum(II) complexes [halo = fluoro:erythro-8-PtI2 (I) and halo = chloro:erythro-9-PtI2 (II)] which were synthesized for application in breast and prostate cancer, have been carried out. The 6239 as well as the 6521 reflexes were ...

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