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Optimization of cisplatin for the treatment of hormone-dependent tumoral diseases Part.2 Use of non-steroidal ligands

Gust, Ronald ; Beck, Wolfgang ; Jaouen, Gerard ; Schönenberger, Helmut


A review. Platinum complexes with carrier ligands were synthesized to overcome intrinsic and acquired resistance of the tumors during the therapy. For the treatment of breast and prostate cancer steroidal and non-steroidal ligands are available. This article is a crit. review of the attempts made during the last 3 decades to design platinum complexes with a selective mode of action against ...


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