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Optimization of cisplatin for the treatment of hormone dependent tumoral diseases Part.1. Use of steroidal ligands

Gust, Ronald ; Beck, Wolfgang ; Jaouen, Gerard ; Schönenberger, Helmut



Abstract

A review. Platinum complexes such as cisplatin and carboplatin are metal based drugs, which are widely used in cancer chemotherapy. However, in the current therapy of hormone-dependent breast and prostate cancer they are not established. This might be the result of intrinsic and acquired resistance of the tumors during the therapy. Therefore, several attempts were done to design platinum ...

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