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Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein

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Marxreiter, Franz
Date of publication of this fulltext: 26 Nov 2010 15:24

Abstract (English)

In familial and sporadic forms of Parkinson disease (PD), alpha-synuclein pathology is present in PD brains in the brain stem nuclei and olfactory bulb (OB) long before Lewy bodies are detected in the substantia nigra. The OB is an active region of adult neurogenesis, where newly generated neurons physiologically integrate. While accumulation of wildtype alpha-synuclein is one of the pathogenic ...


Translation of the abstract (German)

In familiären und idiopathischen Formen des Morbus Parkinson wird früh im Verlauf der Erkrankung pathologische alpha-Synuclein Akkumulation im Bulbus Olfaktorius gefunden. Während die Akkumulation der Wildtypform des präsynaptischen Proteins alpha-Synuclein ein Kennzeichen des idiopathischem Parkinsonsyndroms ist, zeigen Patienten mit einer A30P Punktmutation im alpha-Synuclein Gen einen frühen ...


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