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1,2-Diphenylethylenediamine platinum complexes as antitumor agents

Schönenberger, Helmut ; Von Angerer, Erwin ; Karl, Johann ; Jennerwein, Margaretha ; Engel, Juergen



Abstract

The title compds. I [R = (substituted) Ph; R1 = H, C1-6 alkyl; X = pharmaceutically acceptable anion], useful as antitumor agents, are prepd. by complexation of a 1,2-diphenylethylenediamine ligand by a Pt compd. Thus, 248 mg meso-1,2-bis(4-fluorophenyl)ethylenediamine in 50% aq. Me3COH was treated with 415 mg K2PtCl4 at 50-60 Deg with exclusion of light to give I (R = 4-FC6H4, R1 = H, X = Cl). I ...

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