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Diamineplatinum(II) complex compounds with a hydroxylated 2-phenylindole ring, procedure for their preparation, pharmaceutical compositions containing them, and their use as antitumor agents

Von Angerer, Erwin ; Knebel, Norbert ; Schönenberger, Helmut ; Engel, Juergen


The title compds. I [R1 = H, OH, C2-6 alkanoyloxy; R2, R5, R6 = H, halo; R3 = H, C1-6 alkyl; R4 = OH, C2-6 alkanoyloxy; Alk = C2-10 alkylene (4 neighboring CH2 can be replaced by 1,4-phenylene); AB = NHCH2CH2NH2, (H2NCH2)2CH, Q (R7 = H, C1-6 alkyl, Ph); X = equiv. physiol. tolerable anion], useful as antitumor agents with good tolerability, were prepd. by reaction of a tetrahaloplatinum (II) ...


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