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Zusammenfassung
N-L-Phenylalanyl-L-2-amino-1-phenylpropane (I) was prepd. and its pharmacokinetics was studied in mice following i.p. administration. 14C accumulated in the gastrointestinal tract, liver, kidney, bile, and brain. The radioactivity was mainly excreted by the kidneys (54%) and in the feces (11%); at 48 h postadministration, the metab. of I was nearly complete (85%). In brain, the max. 14C-activity ...
Zusammenfassung
N-L-Phenylalanyl-L-2-amino-1-phenylpropane (I) was prepd. and its pharmacokinetics was studied in mice following i.p. administration. 14C accumulated in the gastrointestinal tract, liver, kidney, bile, and brain. The radioactivity was mainly excreted by the kidneys (54%) and in the feces (11%); at 48 h postadministration, the metab. of I was nearly complete (85%). In brain, the max. 14C-activity was obsd. at 0.25 h postadministration; 93.38% of the radioactivity was assocd. with I and its metabolite amphetamine (II) (quantity ratio of II:I = 1.43) and 5% with the hydroxylated metabolite of II. A continuous increase in spontaneous motility was obsd. in mice up to 4 h after I administration and this was attributed to II.
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