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Studies of pharmacokinetics and metabolic behavior of N-L-phenylalanyl-L-2-amino-1-phenylpropane

Beck, D. ; Hoelzl, J. ; Schönenberger, Helmut


N-L-Phenylalanyl-L-2-amino-1-phenylpropane (I) was prepd. and its pharmacokinetics was studied in mice following i.p. administration. 14C accumulated in the gastrointestinal tract, liver, kidney, bile, and brain. The radioactivity was mainly excreted by the kidneys (54%) and in the feces (11%); at 48 h postadministration, the metab. of I was nearly complete (85%). In brain, the max. 14C-activity ...


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