Go to content
UR Home

Synthesis, in vivo and in vitro studies on the antineoplastic effect of cis-dichloro-dipeptide ester-platinum(II) complexes

Beck, Wolfgang ; Purucker, Bernhard ; Girnth, Michael ; Schönenberger, Helmut ; Seidenberger, Horst ; Ruckdeschel, Gotthard


Cis-Cl2Pt(GlyGlyOEt)2 (I) [60426-60-0] (1.7 * 10-5M) inhibited DNA formation by sarcoma 180, Yoshida sarcoma, and Walker 256 carcinosarcoma in vitro. RNA and protein synthesis were inhibited to a lesser extent. I inhibited growth of Walker 256 carcinosarcoma by 78% at 380 mg/kg i.p. in rats and produced 30% cures; I was less effective against the other tumors in vivo. I caused filamentous growth ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons