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Synthesis, in vivo and in vitro studies on the antineoplastic effect of cis-dichloro-dipeptide ester-platinum(II) complexes

Beck, Wolfgang ; Purucker, Bernhard ; Girnth, Michael ; Schönenberger, Helmut ; Seidenberger, Horst ; Ruckdeschel, Gotthard



Abstract

Cis-Cl2Pt(GlyGlyOEt)2 (I) [60426-60-0] (1.7 * 10-5M) inhibited DNA formation by sarcoma 180, Yoshida sarcoma, and Walker 256 carcinosarcoma in vitro. RNA and protein synthesis were inhibited to a lesser extent. I inhibited growth of Walker 256 carcinosarcoma by 78% at 380 mg/kg i.p. in rats and produced 30% cures; I was less effective against the other tumors in vivo. I caused filamentous growth ...

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