Dokumentenart: | Artikel | ||||
---|---|---|---|---|---|
Titel eines Journals oder einer Zeitschrift: | Zeitschrift für Naturforschung B: Anorganische Chemie, organische Chemie | ||||
Verlag: | Verl. der Zeitschrift für Naturforschung | ||||
Band: | 31B | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 6 | ||||
Seitenbereich: | S. 832-845 | ||||
Datum: | 1976 | ||||
Zusätzliche Informationen (Öffentlich): | CAN 85:137309 1-5 Pharmacodynamics 15663-27-1 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, dichlorodipeptide ester platinum complexes in relation to); 60426-60-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and neoplasm inhibitory activity of); 60399-15-7P; 60399-17-9P; 60399-19-1P; 60399-21-5P; 60399-23-7P; 60399-28-2P; 60399-29-3P; 60399-30-6P; 60554-12-3P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 60426-61-1 Role: BIOL (Biological study) (reaction with amino acid ethyl esters); 459-73-4 Role: BIOL (Biological study) (reaction with amino acid platinum complexes); 10025-99-7 Role: BIOL (Biological study) (reaction with dipeptide ethyl esters); 15654-65-6; 15654-80-5; 21434-59-3 Role: BIOL (Biological study) (reaction with glycine ethyl ester); 26348-61-8 Role: BIOL (Biological study) (reaction with glycine nitrophenol ester platinum complex); 100-02-7 Role: BIOL (Biological study) (reaction with glycine platinum complex); 17567-45-2 Role: BIOL (Biological study) (reaction with nitrophenol); 2087-41-4; 60392-15-6 Role: BIOL (Biological study) (reaction with potassium chloroplatinate) | ||||
Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger | ||||
Identifikationsnummer: |
| ||||
Stichwörter / Keywords: | Bactericides, Disinfectants and Antiseptics Neoplasm inhibitors (dichlorodipeptide ester platinum complexes) Deoxyribonucleic acids Proteins Ribonucleic acids Role: FORM (Formation, nonpreparative) (formation of, by neoplasm, dichlorodipeptide ester platinum complex inhibition of) peptide platinum complex neoplasm inhibitor | ||||
Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe | ||||
Dokumenten-ID: | 18113 |
Zusammenfassung
Cis-Cl2Pt(GlyGlyOEt)2 (I) [60426-60-0] (1.7 * 10-5M) inhibited DNA formation by sarcoma 180, Yoshida sarcoma, and Walker 256 carcinosarcoma in vitro. RNA and protein synthesis were inhibited to a lesser extent. I inhibited growth of Walker 256 carcinosarcoma by 78% at 380 mg/kg i.p. in rats and produced 30% cures; I was less effective against the other tumors in vivo. I caused filamentous growth ...
Zusammenfassung
Cis-Cl2Pt(GlyGlyOEt)2 (I) [60426-60-0] (1.7 * 10-5M) inhibited DNA formation by sarcoma 180, Yoshida sarcoma, and Walker 256 carcinosarcoma in vitro. RNA and protein synthesis were inhibited to a lesser extent. I inhibited growth of Walker 256 carcinosarcoma by 78% at 380 mg/kg i.p. in rats and produced 30% cures; I was less effective against the other tumors in vivo. I caused filamentous growth of Escherichia coli B. A DNA polymerase-deficient strain of E. coli was more strongly inhibited by I than a nondeficient strain. I was prepd. either (1) directly from K2PtCl4 and the dipeptide ester or (2) from the alpha -amino acid complex using Pt as an amino protecting group. Also prepd. Cl2Pt(MetGlyOEt) (II) [60399-21-5], Cl2Pt(ethynyl-GlyOEt) [60399-23-7], cis-Cl2Pt(GlySerOet)2 [60399-28-2], and some corresponding Pd complexes.
Metadaten zuletzt geändert: 24 Mai 2018 12:19